Insulin 3D Structures

(Updated on 30-May-2023)

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• Insulin
  • 5bts, 4ak0, 2lgb, 1guj, 2c8r, 2c8q, 3i40, 3i3z, 5en9, 3zi3, 6s34, 6h3m, 6o17, 6s34, 7ac4, 7jp3, 7qgf, 7s4y, 7z5l, 7z5q, 8gsg - hIns A chain + B chain – human
    
  • 6jr3 - hIns A chain + B chain – Cryo EM
    
  • 3e7y, 3e7z, 2qiu, 1os3, 1os4, 1mso, 1g7a, 1g7b, 1trz, 4eww, 4ewx, 4ewz, 4ex0, 4ex1, 4exx, 4ey1, 4ey9, 4eyd, 4eyn, 4eyp, 4f0n, 4f0o, 4f1a, 4f1b, 4f1c 4f1d, 4f1f, 4f1g, 4f4t, 4f4v, 4f51, 4f8f, 4fg3, 4p65, 2vjz, 2vk0, 3p33, 3w7y, 3w7z, 3w80, 5ems, 5e7w, 5co9, 5co6, 5co2, 6gv0, 6zi8 - hIns A chain + B chain + Zn
    
  • 1fu2, 1fub - hIns A chain + B chain + Zn – powder diffraction
    
  • 5t7r - hIns A chain (mutant) + B chain
    
  • 1b9e, 3u4n, 4iuz, 4une, 4ung, 4unh, 5ena, 2ws4, 7nhu - hIns A chain + B chain (mutant)
    
  • 3bxq, 1qj0, 6tyh – hIns A chain + B chain (mutant) + Zn
    
  • 3ir0, 3inc, 3ilg, 3exx, 2r34, 2r35, 2r36, 3tt8, 4rxw, 4fka, 6p4z - hIns A chain + B chain + non-Zn metal ion
    
  • 1jca, 1j73, 4efx, - hIns A chain (mutant) + B chain + Zn
    
  • 5mwq, 5azz, 6s4i, 6s4j, 6vet - hIns A chain (mutant) + B chain (mutant)
    
  • 6p4z - hIns A chain + B chain + Co + Gd
    
  • 2g4m, 9ins, 3t2a, 4a7e, 5lis, 5fb6, 5d5e, 5d54, 5d53, 5d52 - pIns A chain + B chain – pig
    
  • 1iza - pIns A chain + B chain (mutant)
    
  • 1zni, 4ins, 3ins, 3rto, 3fhp - pIns A chain + B chain + Zn
    
  • 1izb - pIns A chain + B chain (mutant) + Zn
    
  • 2zpp, 2efa - pIns A chain + B chain – Neutron
    
  • 1m5a - pIns A chain + B chain + Co
    
  • 6ins – pIns single chain
    
  • 1aph, 1bph, 1cph, 1dph, 4bs3, 4i5y, 4i5z, 4ihn, 2bn1, 2bn3, 6or0, 6qq7, 6qqg, 6qrh, 6qrk - bIns A chain + B chain – bovine
    
  • 2zp6, 4e7t, 4e7u, 4e7v, 4idw, 2a3g, - bIns A chain + B chain + Zn
    
  • 6zhb - bIns A chain + B chain + Zn – electron diffraction
    
  • 4m4f, 4m4h, 4m4i, 4m4j, 4m4l, 4m4m - bIns A chain + B chain + non-Zn metal ion
    
  • 6q8q - bIns A chain + B chain + Ar
    
• Insulin structures using NMR
  • 1sf1, 2aiy, 3aiy, 4aiy, 5aiy, 1xgl, 2mvc, 2kxk, 2m1e, 2m2m, 2m2n, 2m2o, 2m2p, 2hiu, 2jv1, 6x4x - hIns A chain + B chain – NMR
    
  • 1ai0, 1aiy - hIns A chain + B chain + Zn – NMR
    
  • 1t1k, 1t1p, 1t1q, 2mpg, 2mpi, 2l1z, 5mhd - hIns A chain (mutant) + B chain – NMR
    
  • 2jmn, 2h67, 2hho, 1jco, 1a7f, 2mvd, 2kjj, 2k91, 2rn5, 1hiq, 1hit - hIns A chain + B chain (mutant) – NMR
    
  • 2jum, 2juv, 1k3m, 1vkt, 1hui, 1mhi, 1mhj, 1hls, 1lkq, 2m1d - hIns A chain (mutant) + B chain (mutant) – NMR
    
  • 2kqq, 2l1y - hIns A chain (mutant) + B chain + Ala – NMR
    
  • 2kjr - hIns A chain + B chain (mutant) + Ala – NMR
    
  • 7elj - bIns A chain + B chain + tetrapeptide – NMR
    
  • 2hh4 - hIns A chain + B chain (mutant) + Ser – NMR
    
  • 2kju - hIns A chain + B chain (mutant) + Glu – NMR
    
  • 2juu - hIns A chain (mutant) + B chain (mutant) + Thr – NMR
    
  • 1kmf - hIns A chain (mutant) + B chain (mutant) + Ile – NMR
    
  • 1bzv - hIns A chain (mutant) + B chain (mutant) + Ala – NMR
    
  • 2lwz, 5wbt – hIns single chain - NMR
    
  • 2jzq – hIns single chain (mutant) - NMR
    
  • 1ho0 - bIns B chain (mutant) – NMR
    
  • 5miz, 6kh8, 6kh9, 6kha - bIns A chain + B chain – NMR
    
• Insulin complexes
  • 4xc4 - hIns A chain + B chain + sulfatide + Zn
    
  • 1ben - hIns A chain + B chain + hydroxybenzamide + Zn
    
  • 1tyl, 1tym - hIns A chain + B chain + hydroxyacetanilide + Zn
    
  • 5boq - hIns A chain + B chain + norleucine
    
  • 5bpo - hIns A chain + B chain + norvaline
    
  • 5bqq - hIns A chain + B chain + norvaline + Zn
    
  • 2mli - hIns A chain + B chain + Phe derivative
    
  • 2ws1 - hIns A chain + B chain + Tyr derivative
    
  • 5hqi, 5hpr, 4cxl, 2wrw - hIns A chain + B chain (mutant) + Pro derivative
    
  • 4nib - hIns A chain (mutant) + B chain + Ala
    
  • 3fq9 - hIns A chain (mutant) + B chain + Ala + Zn
    
  • 4cxn, 4cy7, 2wru, 2wrx, 2ws0 - hIns A chain + B chain (mutant) + Ala derivative
    
  • 2wrv - hIns A chain + B chain (mutant) + His derivative
    
  • 2oly, 2om0, 2omh, 2omi - hIns A chain + B chain + urea + resorcinol + Zn
    
  • 2omg - hIns A chain + B chain + urea + cresol + Zn
    
  • 2olz, 2om1 - hIns A chain + B chain + thiocyanate + resorcinol + Zn
    
  • 4akj, 4ajz, 3v19, 1znj - hIns A chain + B chain + phenol + Zn
    
  • 3kq6, 1xw7, 1rwe - hIns A chain (mutant) + B chain + phenol + Zn
    
  • 1w8p, 2ws7, 1qiy - hIns A chain + B chain (mutant) + phenol + Zn
    
  • 1zeg, 1lph - hIns A chain (mutant) + B chain (mutant) + phenol + Zn
    
  • 3v1g - hIns A chain + B chain + phenol + Glu + Zn
    
  • 1q4v - hIns A chain + B chain + phenol + Ile + Zn
    
  • 3rov, 3p2x - hIns A chain + B chain (mutant) + phenol + Ala + Zn
    
  • 5hpu, 5uu4, 5uu3, 5uu2, 5usv, 5uss, 5usp, 5uru, 5urt, 5uqa, 5uoz - hIns A chain + B chain + phenol + Pro derivative + Zn
    
  • 5hrq - hIns A chain + B chain (mutant) + phenol + Pro derivative + Zn
    
  • 3zs2, 3zqr - hIns A chain + B chain + phenol + Phe derivative + Zn
    
  • 2ws6 - hIns A chain + B chain + phenol + Tyr derivative + Zn
    
  • 1xda - hIns A chain + B chain + phenol + myristic acid + Zn
    
  • 6ck2 - hIns A chain + B chain (mutant) + phenol + ornithine + Zn
    
  • 1qiz - hIns A chain (mutant) + B chain (mutant) + resorcinol + Zn
    
  • 1ev3, 1ev6, 1uz9, 4gbn, 4gbc, 4gbi, 4gbk, 4gbl, 6gnq - hIns A chain + B chain + cresol + Zn
    
  • 1zeh - hIns A chain (mutant) + B chain (mutant) + cresol + Zn
    
  • 1evr, 4ajx, 3zu1 - hIns A chain + B chain + resorcinol + Zn
    
  • 5mam - hIns A chain + B chain + serotonin + Zn
    
  • 5mt9, 5mt3 - hIns A chain + B chain + serotonin + arginine + Zn
    
  • 1b17, 1b18, 1b19, 1b2a, 1b2b, 1b2c, 1b2d, 1b2e, 1b2f, 1b2g - pIns A chain + B chain + sulfate
    
  • 1mpj, 3gky, 1wav - pIns A chain + B chain + phenol + Zn
    
  • 2tci - pIns A chain + B chain + thiocyanate + Zn
    
  • 3mth - pIns A chain + B chain + methylparaben + Zn
    
  • 7ins - pIns A chain + B chain + clupeine + cresol + Zn
    
  • 5jyq - CgIns A chain + B chain + Pro derivative – Conus geographus
    
• Insulin complexes with protein
  • 3q6e - hIns A chain + B chain + synthetic receptor
    
  • 7bw7, 7bw8, 7bwa, 7pg0, 7pg2, 7pg3, 7pg4, 7qid, 7sth, 7sti, 7stj, [[7stk, 8guy - hIns A chain + B chain + insulin receptor – Cryo EM
    
  • 7l7j, 7sl1, 7sl2, 7sl3 - hIns A chain (mutant) + B chain + insulin receptor – Cryo EM
    
  • 7sl4, 7sl6 - hIns A chain + B chain (mutant) + insulin receptor – Cryo EM
    
  • 7mqs - hIns A chain (mutant) + B chain (mutant) + insulin receptor – Cryo EM
    
  • 7yq3, 7yq4, 7yq5, 7yq6 - hIns A chain + B chain + insulin receptor + DNA – Cryo EM
    
  • 2g54, 2g56 - hIns B chain + insulin-degrading enzyme + Zn
    
  • 6b3q - hIns A chain + B chain + insulin-degrading enzyme
    
  • 6b3q, 6bfc - hIns A chain + B chain + insulin-degrading enzyme – Cryo EM
    
  • 2wby, 2wc0 - hIns A chain + B chain + insulin-degrading enzyme (mutant) + Zn
    
  • 3w11, 5kqv - hIns A chain + B chain + insulin-degrading enzyme + antibody
    
  • 6b70 - hIns A chain + B chain + insulin-degrading enzyme + antibody – Cryo EM
    
  • 6jk8, 7v3p - hIns A chain + B chain + IGF-1R – Cryo EM
    
  • 5wob - hIns A chain + B chain + insulin-degrading enzyme + antibody + Zn
    
  • 4oga, 6vep - hIns A chain + B chain + insulin receptor + antibody
    
  • 6ce7, 6ce9, 6ceb, 6hn5 - hIns A chain + B chain + insulin receptor – Cryo EM
    
  • 6z7w, 6z7y, 6z7z - pIns A chain + B chain + antibody
    
  • 6z7z - pIns A chain + B chain + antibody
    
  • 7ins - pIns A chain + B chain + clupeine
    
  • 8ez0 - mIns + insulin receptor – Cryo EM
    
  • 6veq - CgIns A chain + B chain + insulin receptor + antibody
    
• Proinsulin
  • 2kqp – hPIns A chain – NMR
    
  • 1t0c - hPIns A chain residues 57-87 – NMR
    
  • 1iog, 1ioh, 1sjt - hPIns A chain (mutant) + B chain (mutant) – NMR
    
  • 1efe – mini-hPIns
    
  • 1sju - mini-hPIns (mutant)
• Despeptide insulin
  • 1his - hDPI A chain + B chain]] - NMR
    
  • 1htv – hDTRI A chain + B chain
    
  • 1sdb - pDPI A chain + B chain
    
  • 1dei – pDHPI A chain (mutant) + B chain (mutant)
    
  • 1pid - bDPI A chain + B chain
    
  • 2ins – bD-Phe Ins chain A + chain B
    
  • 2ceu – DPI – yeast
    
• Leginsulin
  • 1ju8 – Lins A chain residues 1-37 – legume - NMR
    
• Insulin lispro
  • 5udp – LishIns – synthetic
    
  • 6nwv - hIns A chain + hInsLis B chain + cresol + Zn
    
• Insulin glargine
  • 4iyd, 4iyf, 5viz – hIns – synthetic
    

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Jaime Prilusky, Michal Harel, Joel L. Sussman