6z46 | pdb_00006z46
Structure of the S. acidocaldarius 20S proteasome (Saci0613/Saci0662)
Structural highlights
FunctionPSA_SULAC Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Publication Abstract from PubMedSulfolobus acidocaldarius is the closest experimentally tractable archaeal relative of eukaryotes and, despite lacking obvious cyclin-dependent kinase and cyclin homologs, has an ordered eukaryote-like cell cycle with distinct phases of DNA replication and division. Here, in exploring the mechanism of cell division in S. acidocaldarius, we identify a role for the archaeal proteasome in regulating the transition from the end of one cell cycle to the beginning of the next. Further, we identify the archaeal ESCRT-III homolog, CdvB, as a key target of the proteasome and show that its degradation triggers division by allowing constriction of the CdvB1:CdvB2 ESCRT-III division ring. These findings offer a minimal mechanism for ESCRT-III-mediated membrane remodeling and point to a conserved role for the proteasome in eukaryotic and archaeal cell cycle control. The proteasome controls ESCRT-III-mediated cell division in an archaeon.,Tarrason Risa G, Hurtig F, Bray S, Hafner AE, Harker-Kirschneck L, Faull P, Davis C, Papatziamou D, Mutavchiev DR, Fan C, Meneguello L, Arashiro Pulschen A, Dey G, Culley S, Kilkenny M, Souza DP, Pellegrini L, de Bruin RAM, Henriques R, Snijders AP, Saric A, Lindas AC, Robinson NP, Baum B Science. 2020 Aug 7;369(6504). pii: 369/6504/eaaz2532. doi:, 10.1126/science.aaz2532. PMID:32764038[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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