Structural highlights
3qph is a 1 chain structure with sequence from Pyrococcus furiosus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 2.992Å |
| Ligands: | ACT, FRU, GLC, GOL, PRD_900003 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
TRMBR_PYRFU Inhibits transcription of the trehalose/maltose transport gene cluster (malE operon) and of the maltodextrin transport gene cluster (mdxE operon). Acts by binding to two different operator sequences in both promoters, preventing polymerase recruitment and transcription.[1] [2]
See Also
References
- ↑ Lee SJ, Engelmann A, Horlacher R, Qu Q, Vierke G, Hebbeln C, Thomm M, Boos W. TrmB, a sugar-specific transcriptional regulator of the trehalose/maltose ABC transporter from the hyperthermophilic archaeon Thermococcus litoralis. J Biol Chem. 2003 Jan 10;278(2):983-90. PMID:12426307 doi:10.1074/jbc.M210236200
- ↑ Lee SJ, Moulakakis C, Koning SM, Hausner W, Thomm M, Boos W. TrmB, a sugar sensing regulator of ABC transporter genes in Pyrococcus furiosus exhibits dual promoter specificity and is controlled by different inducers. Mol Microbiol. 2005 Sep;57(6):1797-807. PMID:16135241 doi:10.1111/j.1365-2958.2005.04804.x
