3phw | pdb_00003phw

OTU Domain of Crimean Congo Hemorrhagic Fever Virus in complex with Ubiquitin

spinqualitylabelsall models 3phw, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3phw is a 8 chain structure with sequence from Crimean-Congo hemorrhagic fever virus strain IbAr10200 and Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2Å Ligands: NEH Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function L_CCHFI Displays RNA-directed RNA polymerase, deubiquitinating and deISGylase activities. RNA-dependent RNA polymerase is responsible for replication and transcription of the viral RNA genome. The deubiquitinating activity cleaves both ubiquitinated and ISGylated products and may therefore regulate ubiquitin and ISG15 dependent innate immunity. See Also RNA polymerase 3D structures

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