2vn8 | pdb_00002vn8

Crystal structure of human Reticulon 4 interacting protein 1 in complex with NADPH

spinqualitylabelsall models 2vn8, resolution 2.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2vn8 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.1Å Ligands: CIT, GOL, NA, NDP Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease RT4I1_HUMAN Autosomal recessive isolated optic atrophy. The disease is caused by variants affecting the gene represented in this entry. Function RT4I1_HUMAN Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury.[UniProtKB:Q924D0] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

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