BtuB

spinqualitylabelsall models E. coli BtuB complex with cobalamin (a vitamin B12 derivative), lipid, methanesulfonothioate derivative and Ca+2 ions (green) (PDB code 3m8d) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function BtuB or vitamin B12 receptor or outer membrane cobalamin transporter is an outer membrane receptor found in a variety of bacteria, such as E. coli. BtuB transports vitamin B12 across the membrane of gram-negative bacteria. The transport is achieved with high affinity by the collaboration of BtuB and the periplasmic protein TonB. As an essential receptor for the cell that is constitutively expressed, it is an ideal target to be parasitized, a feature exploited by a variety of proteins such as Colicins. Structural highlights BtuB depends on the presence of Ca+2 ions for high affinity binding of cobalamin (a form of vitamin B12). The Ca+2 ions are coordinated to several Asp side chains. 3D structure of BtuB BtuB 3D structures

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