7wji | pdb_00007wji

Architecture of the human NALCN channelosome

spinqualitylabelsall models 7wji, resolution 4.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7wji is a 5 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 4.5Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease UNC80_HUMAN Hypotonia-speech impairment-severe cognitive delay syndrome. The disease is caused by variants affecting the gene represented in this entry. Function UNC80_HUMAN Auxiliary subunit of the NALCN sodium channel complex, a voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability (By similarity). Activated by neuropeptides substance P, neurotensin, and extracellular Ca(2+) that regulates neuronal excitability by controlling the sizes of NALCN-dependent sodium-leak current. UNC80 is essential for NALCN sensitivity to extracellular Ca(2+) (By similarity).[UniProtKB:Q8BLN6] See Also Calmodulin 3D structures

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