Integrin 3D structures

3D structures of integrin

Updated on 25-September-2025

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• IG CR3
  • 1ido – hIG I domain + Mg – human
  • 1jlm - hIG I domain + Mn
• IG α-1

**4a0q - hIG I domain 166-366 (mutant) + Mg

• • 2l8s - hIG transmembrane domain 1135-1179 – NMR
    
  • 5hgj - hIG VWFA domain
    
  • 2m32 - hIG I domain + collagen peptide
    
  • 1ck4 - rIG I domain – rat
  • 1mhp - rIG I domain (mutant) + antibody + Mn
  • 2b2x - rIG I domain (mutant) + antibody + Mg
• IG α-2
  • 4bj3, 5e6v, 5e6x - hIG I domain
    
  • 1dzi, 4bj3 - hIG I domain + collagen peptide
  • 1v7p - hIG I domain (mutant) + EMS16 + Mn
  • 5thp, 6nd8, 6nd9, 6nda, 6ndb, 6ndc, 6ndd, 6nde, 6ndf, 6ndg, 6ndh - hIG residues 170-366 + rhodocetin
    
• IG α-1 + IG β-1
  • 1qc5, 1qcy - hIG I domain (mutant) + Mg
  • 1pt6 - hIG I domain + Mg
• IG α-2 + IG β
  • 5hj2 - hIG I domain
    
  • 1aox - hIG I domain (mutant)
  • 2k1a - hIG transmembrane domain – NMR
    
• IG α-2b + IG β-3
  • 4cak, 8gcd, 8gce, 8t2v, 9dax – hIG – Cryo EM
    
  • 8t2u – hIG + drug – Cryo EM
    
  • 1kup, 1kuz – hIG proximal domain – NMR
    
  • 1m8o - hIG cytoplasmic domain – NMR
    

**2k9j, 2knc, 7kn0 - hIG transmembrane domain – NMR

• • 1tye, 3fcs, 3fcu – hIG + Mg
  • 3fc3 – hIG (mutant) + Mg
  • 2vc2, 2vdk, 2vdl, 3nid, 3nif, 3nig, 3zdx, 3zdy, 3zdz, 3ze0, 3ze1, 3ze2, 5hdb – hIG headpiece + antibody + Mg
  • 4z7n, 4z7o, 4z7q – hIG headpiece + antibody + Mg + tetrapeptide
    
  • 2vdm, 2vdn, 3t3m, 3t3p – hIG headpiece + antibody + antagonist + Mg
  • 2vdo, 2vdp, 2vdq, 2vdr – hIG headpiece + antibody + fibrinogen peptide + Mg
  • 6v4p, 7la4, 9axl, 9dao – hIG + antibody – Cryo-EM
    
  • 9deq, 9der – hIG + drug – Cryo-EM
    
  • 7l8p, 7tct, 7td8, 7tho, 7tmz, 7tpd, 7u60, 7u9f, 7u9v, 7ubr, 7ucy, 7udg, 7udh, 7ue0, 7ufh, 7uh8, 7uje, 7ujk, 7uk9, 7uko, 7ukp, 7ukt – hIG + antibody + drug
    
• IG α-4
  • 4irz - hIG + antibody
    
• IG α-4 + IG β-7
  • 3v4p - hIG headpiece (mutant) + antibody + Mg
  • 3v4v - hIG headpiece (mutant) + antibody + inhibitor + Mg
• IG α-5 + IG β-1
  • 7nxd – hIG + Mg – Cryo-EM
    
  • 7nwl – hIG + fibronectin + laminin – Cryo-EM
    
  • 4wjk - hIG headpiece (mutant) + Mg
    
  • 4wk0, 4wk2, 4wk4 - hIG headpiece (mutant) + peptide + Mg
    
  • 9b9j, 9b9k, 9nab – hIG + antibody – Cryo-EM
    
  • 9ckv, 9dia, 9ef2 – hIG + NeoNectin – Cryo-EM
    
  • 3vi3 - hIG headpiece + antibody + Mg
  • 3vi4 - hIG headpiece + antibody + peptide + Mg
  • 8oxz - rIG headpiece – Cryo EM
    
• IG α-5 + IG β-3 ectodomain
  • 1m1x, 1u8c, 3ije, 4g1e, 4g1m – hIG + cation
  • 4mmx, 4mmy, 4mmz - hIG + Mn + fibronectin domain 10
    
  • 4o02, 6avq, 6avr, 6avu - hIG + antibody
    
  • 1jv2 - hIG + platelet membrane glycoprotein IIIA + Ca
  • 1l5g - hIG + tripeptide + Mn
• IG α-5 + IG β-6
  • 4um8 – hIG headpiece (mutant) + Ni
    
  • 5ffg – hIG headpiece + Ca
    
  • 4um9, 5ffo – hIG headpiece (mutant) + Mg + transforming growth factor β 3
    
  • 5nem, 5ner, 5net, 5neu – hIG headpiece + foot-and-mouth virus – Cryo EM
    
  • 5ffo – hIG headpiece + TGF-beta-1
    
• IG α-6 + IG β-1
  • 7ceb, 7cec – hIG headpiece + laminin + Mg
    
• IG α-E + IG β-7
  • 8zjf – hIG – Cryo EM
    
• IG α-L
  • 1lfa - hIG I domain + Mn
    
  • 1zon, 4ixd, 7kc3 - hIG I domain 153-334
    
  • 1mqa - hIG I domain (mutant)
    
  • 1zoo, 1zop, 3f74 - hIG I domain + Mg
    
  • 1mq9 - hIG I domain (mutant) + Mn
    
  • 1mjn - hIG I domain (mutant) + Mg
    

**2k8o – hIG cytoplasmic domain (mutant) – NMR
 

• • 5e6s, 5e6r – hIG AI, headpiece,pocket domains + Mg
    
  • 2m3e – hIG transmembrane domain - NMR
    
    
• IG α-L complexes
  • 1cqp - hIG I domain + lovastatin + Mg
    
  • 1mq8, 3bn3, 3tcx - hIG I domain (mutant) + intracellular adhesion molecule + Mg
    
  • 1t0p - hIG I domain + intracellular adhesion molecule-3 + Mg
    
  • 1rd4, 2ica, 3bqm, 3bqn, 3e2m - hIG I domain + inhibitor
    
  • 2o7n, 3m6f - hIG I domain + antagonist
    
  • 1xdd, 1xdg, 1xuo, 7kc5 - hIG I domain + inhibitor + Mg
    
  • 7kc6 - hIG I domain + drug + Mg
    
  • 3f78 - hIG I domain + anesthetic + Mg
    
  • 3eoa, 3eob - hIG I domain + antibody
    
  • 3hi6 - hIG I domain (mutant) + antibody + Mn
    
• IG α-L + IG β-2
  • 5e6u – hIG headpiece (mutant) + Ni
    
• IG α-M
  • 1idn, 1na5 - hIG
    
  • 1mf7 - hIG (mutant)
    
  • 1bho - hIG + Mg
    
  • 1bhq - hIG + Cd
    
  • 1m1u - hIG (mutant) + Ca
    
  • 1n9z - hIG (mutant) + Mg
    
  • 3q3g, 3qa3 – hIG + antibody
    
  • 4m76 – hIG + complement C3
    
  • 2lke, 2lkj – hIG cytoplasmic domain – NMR
    
    
  • 8voh, 8voi – hIG I domain + pleiotrophin – NMR
    
    
  • 4xw2 – hIG + simvastatin
    
  • 6rhv, 6rhw – hIG + cytolysin
    
• IG α-M + IG β-2
  • 7usm – hIG ectodomain – Cryo EM
    
  • 7usl – hIG ectodomain + adenylate cyclase toxin + antibody – Cryo EM
    
  • 7p2d – hIG ectodomain + nanobody
    
• IG α-V + IG β-1
  • 8w30 – hIG headpiece + inhibitor
    
• IG α-V + IG β-3
  • 8ij5, 8xei, 8xek, 8xen, 8xez – hIG – Cryo EM
    
  • 8xer, 8xf6, 8xfg, 8xfo, 9jei – hIG + drug – Cryo EM
    
  • 9iuj - hIG + rhodostomin – Cryo EM
    
  • 6mk0 – hIG + antagonist
    
  • 6msl – hIG + cysteine knot protein
    
  • 6msu – hIG + EETI-II
    
  • 6naj – hIG + fibronectin
    
• IG α-V + IG β-6
  • 8tcf, 8tcg – hIG + miniprotein inhibitor – Cryo EM
    
  • 9cz7, 9cza, 9czd, 9czf – hIG + antibody – Cryo EM
    
• IG α-V + IG β-8
  • 6djp, 6ujb, 6ujc, 9ind – hIG + antibody – Cryo EM
    
  • 6om1 – hIG (mutant)
    
  • 6om2 – hIG (mutant) + Protgf-b1 RGD peptide
    
  • 6uja – hIG + Protgf-b1 RGD – Cryo EM
    
  • 7y1t, 8vs6, 8vsd – hIG + TGF-b1 – Cryo EM
    
• IG α-X
  • 2luv – hIG cytoplasmic domain – NMR
    
  • 1n3y – hIG domain I (mutant)
    
• IG α-X + IG β-2
  • 3k6s, 3k71, 3k72, 5es4 – hIG + Mg
  • 4neh, 4nen – hIG (mutant) + Mg
    
• IG β-1
  • 8rpq - hIG transmembrane domain 726-761 – NMR
    
• IG β-1D
  • 3g9w – hIG cytoplasmic tail + talin 2 F2-F3 domain
    
• IG β-2
  • 2p26, 2p28, 5e6w – hIG phe2 + phe3 domains
  • 1yuk – hIG chain A PSI domain + chain B I-EGF domain
    
  • 5zaz – hIG transmembrane domain - NMR
    
• IG β-3
  • 1s4x, 2kv9, 2ljd, 2lje, 2ljf – hIG cytoplasmic domain – NMR
    
  • 2rmz, 2rn0 – hIG transmembrane domain – NMR
    
  • 2l91 - hIG transmembrane domain (mutant) – NMR
    
  • 2l1c – hIG cytoplasmic tail + SHC
    
  • 2mtp – hIG cytoplasmic tail (mutant) + hIG α-2 β peptide+ filamin rod domain
    
  • 6bxb, 6bxf – hIG/hIG α-L
    
• IG β-4 or Gp150
  • 2f7q, 3f7r, 1qg3, 3f7q, 4wtw, 4wtx - hIG fibronectin type III domain
  • 2yrz – hIG fibronectin type III domain – NMR
    
  • 3f7p, 4q58 - hIG fibronectin type III domain + plectin-1
  • 6gvl - hIG fibronectin type III domain + dystonin
    
  • 6gvk - hIG fibronectin type III domain (mutant) + dystonin
    
  • 3fq4, 3fso, 3h6a – hIG Calx-β domain
  • 6hyf - rIG fibronectin type III domain
    
• IG β-7
  • 2brq, 2jf1 – hIG cytoplasmic tail + filamin rod domain
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel