MDM2 3D structures

3D structures of MDM2

Updated on 15-December-2025

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• MDM2 ); Domains – p53-binding 24-220; ring – 383-446; C4 zinc-finger 429-491
  • 8bgu - hMDM2 + RNA - human
    
  • 2ruh - hMDM2 p53-binding domain
    
  • 1z1m – hMDM2 p53-binding domain - NMR
    
  • 2c6a, 2c6b – hMDM2 C4 Zinc-finger domain - NMR
    
  • 2hdp - hMDM2 C4 ring-finger domain - NMR
    
  • 6sqp - cMDM2 C4 ring-finger domain – cat
    
  • 4ipf, 4j74 – fMDM2 p53-binding domain (mutant) - frog
    
  • 7ahy - fMDM2 RING domain
    
  • 7ah2 - MDM2 RING domain – zebrafish
    
• MDM2 p53-binding domain complex with small molecule
  • 1rv1, 1t4e, 3lbk, 4dij, 3vzv, 3w69, 3lkb, 4lwt, 4lwu, 4lwv, 4oq3, 5hmh, 5hmi, 5hmk – hMDM2 (mutant) + inhibitor
    
  • 3jzk, 3lbl, 3tu1, 4ere, 4erf, 3tj2, 4hbm, 4jv7, 4jv9, 4jve, 4jvr, 4jwr, 4mdn, 4mdq, 4oas, 4oba, 4occ, 4ode, 4odf, 4ogn, 4ogt, 4ogv, 4qo4, 4hg7, 4wt2, 4qoc, 4wt2, 4zfi, 4zgk, 4zyf, 4zyi, 5j7f, 5j7g, 5lav, 5law, 5lay, 5laz, 5ln2, 5trf, 6q96, 6q9h, 6q9l, 6q9o, 6i3s, 6ggn, 5oc8, 5oai, 6i29, 7bir, 7bit, 7biv, 7bj0, 7bj6, 7bmg, 7na1, 7na2, 7na3, 7na4, 7qdq, 8aeu - hMDM2 + inhibitor
    
  • 5z02, 5zxf - hMDM2 +  nutlin
    
  • 8pwc - hMDM2 + brigimadlin
    
  • 2lzg - hMDM2 + inhibitor – NMR
    
  • 3vbg - hMDM2 + indolyl hydantoin
    
  • 5c5a - hMDM2 (mutant) +  inhibitor – NMR
    
  • 1ttv - fMDM2 (mutant) + inhibitor – NMR
    
  • 4j3e, 4j7d, 4j7e, 4jrg, 4jsc, 4zyc, 4lwt, 4lwu, 4lwv - fMDM2 (mutant) + inhibitor
    
• MDM2 complex with peptide
  • 1t4f, 4hfz - hMDM2 (mutant) p53-binding domain + p53 peptide
    
  • 3v3b, 7ad0, 7nus - hMDM2 p53-binding domain + p53 peptide
    
  • 2mps - hMDM2 p53-binding domain + p73 peptide
    
  • 3jzr - hMDM2 p53-binding domain + pDI6W peptide
    
  • 4umn - hMDM2 p53-binding domain + M06 peptide
    
  • 3jzs - hMDM2 p53-binding domain + pDIQ peptide
    
  • 3tpx - hMDM2 p53-binding domain + D-peptide inhibitor
    
  • 2axi, 2gv2, 3eqs, 3g03, 3iux, 3lnj, 3lnz, 3iwy, 5umm, 6hfa, 7kjm, 8f0z, 8f10, 8f12, 8f13, 8gcg, 8j81, 9cdz, 9fql - hMDM2 p53-binding domain + peptide inhibitor
    
  • 5vk0, 6kzu, 6aaw, 9gfc, 9gfk - hMDM2  p53-binding domain + stapled peptide
    
  • 4ud7, 4ue1, 4umn, 5afg, 5xxk, 6h22, 6t2d, 6t2e, 6t2f, 6y4q - hMDM2  p53-binding domain (mutant) + stapled peptide
    
  • 5wts - hMDM2 p53-binding domain + GFP-linked peptide
    
  • 2m86 - hMDM2 p53-binding domain + cyclotide - NMR
    
  • 2vje, 2vjf - hMDM2 ring domain + MDM4 peptide
    
  • 1ycq, 1ycr – fMDM2 p53-binding domain + p53 peptide
    
• MDM2 complex with protein
  • 5mnj - hMDM2 C4 zinc-finger domain + MDM4 + polyubiquitin + ubiquitin-conjugating enzyme E2
    
  • 5swk - hMDM2  p53-binding domain + cysteine protease inhibitor
    
  • 6im9 - hMDM2  p53-binding domain + copper reflux oxidase
    
  • 7aye - hMDM2  p53-binding domain + DsbD
    
  • 8ei9, 8eia, 8eib, 8eic - hMDM2 p53-binding domain + catenin + helicon peptide
    
  • 6sqo - hMDM2  ring domain + ubiquitin-conjugating enzyme E2 + S27A
    
  • 6sqr, 6sqs - cMDM2  ring domain + ubiquitin-conjugating enzyme E2 + S27A
    
  • 7ahz, 7ai0, 7ai1 - fMDM2 RING domain (mutant) + polyubiquitin + ubiquitin-conjugating enzyme E2
    

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Michal Harel