NADPH oxidase 3D structures

3D structures of NADPH oxidase

Updated on 24-March-2026

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• Neutrophil cytosol factor 1 or p47phox
  • 1ng2, 1uec – hNCF1 SH3 domain 151-340 - human
    
  • 7yxw – hNCF1 SH3 domain (mutant) + p22 + phox peptide
    
  • 1kq6, 1o7k – hNCF1 PX domain 1-123
    
  • 1gd5 – hNCF1 PX domain - NMR
    
• Neutrophil cytosol factor 2 or p67phox
  • 2dmo – hNCF2 SH3 domain 242-297 - NMR
    
  • 1wm5 – hNCF2 TPR domain 1-213
    
  • 1e96 – hNCF2 TPR domain + Rac + GTP
    
  • 1hh8 – hNCF2 TPR domain (mutant)
    
• Neutrophil cytosol factor 4 or p40phox
  • 2dyb – hNCF4
    
  • 1w6x – hNCF4 SH3 domain 174-228
    
  • 1z9q – hNCF4 SH3 domain - NMR
    
  • 1h6h – hNCF4 PX domain + phosphatidylinositol phosphate
    
• Neutrophil cytosol factor 1+2 p47phox+p67phox
  • 1k4u – hNCF1 peptide + hNCF2 C-terminal SH3 domain 455-516 (mutant) - NMR
    
  • 8wej – hNCF1 + hNCF2 + cytochrome b245 + GTPase + antibody – Cryo EM
    
• Neutrophil cytosol factor 1+4 p47phox+p40phox
  • 1w70 – hNCF1 peptide + hNCF4 SH3 domain
    
• Neutrophil cytosol factor 2+4 p67phox+p40phox
  • 1oey – hNCF2 PB1 domain 352-429 + hNCF4 PB1 domain 237-339 (mutant)
    
• Neutrophil cytosol factor 1 + flavocytochrome b558 a p47phox+p22phox
  • 1ov3 – hNCF1 SH3 domain + b558 149-166
    
  • 1wlp – hNCF1 SH3 domain + b558 1-25 - NMR
    
• gp91phox
  • 3a1f – hgp91 NADPH binding domain 385-570
    
• NADPH oxidase
  • 7u8g – hNOX2 core + antibody – Cryo EM
    
  • 8u7y, 8u85, 8u86, 8u87 – hNOX5 + heme + FAD + NADP – Cryo EM
    
  • 2cdu – NOX + ADP – Fructilctobacillus sanfranciscnsis
    
  • 8qt6 – SpNOX + heme + FAD – Streptococcus pneumoniae – Cryo EM
    
  • 8qq7 – SpNOX + heme + FAD
    
  • 8qq5 – SpNOX DH domain 177-396 + FAD
    
  • 8qt7, 8qta – SpNOX + heme + FAD + NADP – Cryo EM
    
  • 8qt9 – SpNOX + heme + FAD + NAD – Cryo EM
    

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Michal Harel