Phospholipase C

spinqualitylabelsall models Structure of phosphatidylinositol-specific phospholipase C complex with myo-inositol (PDB code 1ptg). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Phospholipase C (PLC) cleaves phospholipids before the phosphate group. PLCs catalyze the conversion of phosphatidylinositol 4,5-bisphosphate to inositol 1,4,5-trisphosphate and diacylglycerol. Phospholipase C β is a key enzyme in mammalian taste signal transduction. For more details on phospholipase C β see PLC beta 3 Gq. Phospholipase C γ is a physiological guanine nucleotide exchange factor for the nuclear GTPase. Phospholipase C δ is critical for Ca+2 homeostasis. Phospholipase C ε is an effector for Ras. Phosphatidylinositol-specific phospholipase C (PIPLC) catalyzes the hydrolysis of phosphatidylinositol into inositol triphosphate and deacylglycerol. PIPLC functions at the plasma membrane. PIPLC can release phosphatidylinositol-linked proteins (i.e., acetylcholinesterase) from the membrane by enzymatically cleaving their GPI anchor. . See also IP3 is second messenger. Disease Phospholipase C γ gene blocking can stop breast cancer. Phospholipase C δ has important suppressive role in the development and progression of esophageal carcinoma. Mutations in phospholipase C δ1 cause hereditary leukonychia. Mutations in phospholipase C ε1 are associated with stomach cancer risk and nephrotic syndromes. Structural highlights The active site of PIPLC is located at a solvent-accessible cleft at the C-terminal. Solvent-accessible cleft.

3D structures of phospholipase C

Phospholipase C 3D structures

Updated on 11-May-2026

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• PIPLC
  • PLC beta 3 Gq – BcPIPLC – Bacillus cereus
    
  • IP3 is second messenger, 3ptd, 4ptd, 5ptd, 6ptd, 7ptd – BcPIPLC (mutant)
    
  • 2plc – LmPIPLC – Listeria monocytogenes
    
  • 3ea1 – BtPIPLC – Bacillus thuringiensis
    
  • 1t6m, 2or2, 3ea3 – BtPIPLC (mutant)
    
  • 3v18 – SaPIPLC – Staphylococcus aureus
    
  • 4f2t, 4f2u, 4i8y, 4i9m – SaPIPLC (mutant)
    
  • 5fyo, 5fyp – PsPIPLC – Pseudomonas
    
• PIPLC complex
  • 1ptg – BcPIPLC + myo-inositol
    
  • 1gym – BcPIPLC + glucosamine-myo-inositol
    
  • 1aod – LmPIPLC + myo-inositol
    
  • 3ea2 – BtPIPLC + myo-inositol
    
  • 5fyr – PsPIPLC + myo-inositol
    
  • 3v16, 4f2b, 4rv3 – SaPIPLC + myo-inositol
    
  • 3v1h, 4i9t, 4s3g – SaPIPLC (mutant) + myo-inositol
    
  • 4i90 – SaPIPLC (mutant) + choline
    
  • 4i9j – SaPIPLC (mutant) + diC4PC
    
• Phospholipase C β
  • 2zkm – hPLCB-2 - human
    
  • 2fju – hPLCB-2 + RAC1
    
  • 8emv – hPLCB-3 – Cryo EM
    
  • 7sq2, 4gnk, 4qj3 – hPLCB-3 + guanine nucleotide-binding protein G subunit alpha
    
  • 4qj4, 4qj5 – hPLCB-3 + guanine nucleotide-binding protein G subunit alpha + inositol phosphate derivative
    
  • 7sq2 – hPLCB-3 + guanine nucleotide-binding protein G subunit alpha + GDP
    
  • 8emw, 8emx – hPLCB-3 + guanine nucleotide-binding protein G subunits beta+gamma – Cryo EM
    
  • 1jad – PLCB - turkey
    
  • 3qr0 – PLCB - cuttlefish
    
  • 3qr1 – PLCB - squid
    
• Phospholipase C γ
  • 1hsq, 2hsp – hPLCG SH3 domain - NMR
    
  • 4fbn – hPLCG-1
    
  • 2k2j – hPLCG-2 split PH2 domain - NMR
    
  • 2w2w – hPLCG-2 split PH2 domain (mutant)
    
  • 2w2x – hPLCG-2 split PH2 domain + RAC2 br />
  • 4ey0 – hPLCG-1 SH2 domain (mutant)
    
  • 7nxe – hPLCG-1 SH2 domain + peptide
    
  • 2pld, 2ple – PLCG C terminal SH2 domain + PDGF peptide – bovine - NMR
    
  • 6pbc – rPLCG-1 – rat
    
  • 1ywp – rPLCG-1 SH3 domain 790-851
    
  • 1y0m – rPLCG-1 SH3 domain (mutant)
    
  • 2fjl – rPLCG-1 split PH2 domain - NMR
    
  • 2eob – rPLCG-2 SH2 domain 633-743 - NMR
    
  • 1ywo – rPLCG-1 SH3 domain + lymphocyte cytosolic protein peptide
    
  • 7z3j – rPLCG-1 + inositol-3P
    
  • 4k44, 4k45 – rPLCG C terminal SH2 domain
    
  • 2dx0 – mPLCG-2 N terminal SH2 domain – mouse
    
  • 2eqi – mPLCG-2 SH3 domain - NMR
    
• Phospholipase C δ
  • 1mai – rPLCD-1 PH domain + inositol triphosphate
    
  • 1qas, 1qat, 1djg, 1djh, 1dji, 2isd – rPLCD-1
    
  • 1djx, 1djy – rPLCD-1 + inositol triphosphate
    
  • 1djz, 1djw – rPLCD-1 + inositol phosphate derivative
    
• Phospholipase C ε
  • 2bye – hPLCE-1 RA1 domain - NMR
    
  • 2byf – hPLCE-1 RA2 domain - NMR
    
  • 6pmp – rPLCE-1 RA1 domain
    
• Phospholipase C
  • 8hav, 8haw – BcPLC4 (mutant) – Arabidopsis thaliana
    
  • 1ah7 – BcPLC
    
  • 1p5x, 2ffz, 2fgn, 2huc – BcPLC (mutant)
    
  • 1p6d, 1p6e – BcPLC (mutant) + phosphocholine derivative
    
  • 1ca1, 1qm6, 1qmd, 1gyg, 1kho, 2wxt – CpPLC – Clostridium perfringensbr />
  • 2wxu, 2wy6 – CpPLC (mutant)
    

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