Pseudouridine synthase 3D structures

3D Structures of pseudouridine synthase

Updated on 20-August-2026

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• Pseudouridine synthase or tRNA pseudouridine synthase
  • 4iqm, 4its, 4j37, 4nz6 – hPUS1 catalytic domain 83-394 - human
    
  • 4nz7 - hPUS1 catalytic domain (mutant)
    
  • 9f9q – hPUS3 (mutant) – Cryo EM
    
  • 5vbb – hPUS C-like
    
  • 8jfx – hPUS TruB 58-318
    
  • 7mzv – yPUS7 - yeast
    
  • 1ze1 – TmPUS B – Thermotoga maritima
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  • 1vio - HiPUS RsuA – Haemophilus influenzae
    
  • 6gut – HiPUS/PILA
    
  • 1dj0 – EcPUS I – Escherichia coli
    
  • 1ksk, 1ksl, 1ksv – EcPUS RsuA
    
  • 4lab - EcPUS RluB catalytic domain
    
  • 1xpi - EcPUS RluC catalytic domain
    
  • 1v9k - EcPUS RluC C-terminal domain (mutant)
    
  • 2ist - EcPUS RluD
    
  • 1prz, 1qyu, 1v9f - EcPUS RluD catalytic domain
    
  • 2olw - EcPUS RluE
    
  • 2oml - EcPUS RluE catalytic domain
    
  • 2gml - EcPUS RluF catalytic domain
    
  • 1si7, 1szw, 1sb7 - EcPUS TruD
    
  • 1vs3 – PUS TruA – Thermus thermophilus
    
  • 1sgv – PUS TruB – Mycobacterium tuberculosis
    
  • 8q70 – PfPUS A – Pyrococcus furiosus
    
• Pseudouridine synthase complex with RNA
  • 8okd, 9enb, 9enc, 9ene, 9enf – hPUS3 + tRNA – Cryo EM
    
  • 9h51 – hPUS1 in 28S ribosome – Cryo EM
    
  • 7r9f – yPUS1 + RNA
    
  • 7r9g – yPUS1 (mutant) + RNA
    
  • 1k8w – EcPUS B + stem-loop RNA
    
  • 9cl9 – EcPUS B in 50S ribosome – Cryo EM
    
  • 7bl5 – EcPUS D in 50S ribosome – Cryo EM
    
  • 1zl3 - EcPUS B (mutant) + stem-loop RNA
    
  • 2i82 – EcPUS RluA + RNA
    
  • 4lgt – EcPUS RluB + RNA
    
  • 3dh3 - EcPUS RluF + RNA
    
  • 2nqp, 2nr0, 2nre – EcPUS TruA + Leu-tRNA
    
  • 1r3e, 1r3f - EcPUS B + RNA
    
  • 3hjw, 3lwo, 3lwp, 3lwq, 3lwr, 3lwv – PfPUS Cbf5 + ribosome biogenesis protein Nop10 + ribosomal protein L7 + RNA
    
  • 3mqk - PfPUS Cbf5 + ribosome biogenesis protein Nop10 + small nuclear RNP Gar1-like protein + RNA
    
  • 3hjy - PfPUS Cbf5 + ribosome biogenesis protein NOP10 + RNA
    
  • 1ze2 - TmPUS B + RNA
    
  • 2ab4 - TmPUS B (mutant) + RNA
    
  • 6yxx, 6yxy, 7aoi – TbPUS in 50S ribosome – Trypanosoma brucei - Cryo EM
    
  • 9hny – TbPUS in 30S ribosome - Cryo EM
    
  • 7am2 – PUS in 50S ribosome – Leishmania tarntolae - Cryo EM
    
• Probable pseudouridine synthase
  • 2apo – PPUS + ribosome biogenesis protein Nop10 – Methanocaldococcus jannaschii
    
  • 2ey4 - PfPPUS Cbf5 + ribosome biogenesis protein Nop10 + small nucleolar RNP
    
  • 2hvy, 3hax - PfPPUS B + ribosome biogenesis protein Nop10 + ribosomal protein L7 + RNA
    
  • 2rfk - PfPUS B + ribosome biogenesis protein Nop10 + small nucleolar RNP + RNA
    
  • 3hay - PfPPUS B + ribosome biogenesis protein Nop10 + ribosomal protein L7 + small nucleolar RNP + RNA
    
  • 2aus – PPUS B + ribosome biogenesis protein Nop10 – Pyrococcus abyssi
    
  • 1z2z – PPUS D – Methanosarcina mazei
    

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Michal Harel