Pyrin domain

spinqualitylabelsall models NMR structure of pyrin domain in human NLRP7, 2km6 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Pyrin domain (PYD) is a protein domain known as death fold. This domain allows the protein to interact with other pyrin domains. It is also known as PYD or PAAD/DAPIN or marenostrin domain. Proteins containing pyrin domain are involved in inflammation and apoptosis. The NALP proteins contain domains NACHT, LRR and PYD and are part of the inflammasome. A 781-amino acid protein named pyrin contains a PYD domain in its N-terminal. Disease Mutations in the protein are the cause of Familial Mediterranean fever.

3D Structures of Pyrin domain

Pyrin domain 3D structures

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Michal Harel, Joel L. Sussman