Pyruvate kinase 3D structures

3D structures of pyruvate kinase

Updated on 14-September-2026

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• Pyruvate kinase muscle
  • 1t5a, 1zjh, 3bjf, 3bjt, 9hib - hPyK M2 muscle - human
    
  • 3g2g, 4qg6, 4qg8, 4qg9, 4qgc, 4wj8, 4yj5, 6b6u, 8hgf - hPyK M2 muscle (mutant)
    
  • 3srf, 3srh – hPyK M1 muscle
    
  • 6wp3, 6wp4, 6wp5, 6wp6 – hPyK M2 muscle (mutant)
    
  • 1pkm, 1pyk – PyK muscle – cat
    
  • 1f3w, 8f5t – rPyK muscle – rabbit
    
  • 1f3x, 7r6y - rPyK muscle (mutant)
    
• Pyruvate kinase muscle binary complexes
  • 4b2d, 9hic - hPyK M2 muscle + fructose bisphosphate
    
  • 4rpp - hPyK M2 muscle (mutant) + fructose bisphosphate
    
  • 4fxj - hPyK M2 muscle + phenylalanine
    
  • 6gg3 - hPyK M2 muscle + alanine
    
  • 6gg4 - hPyK M2 muscle + phenylalanine
    
  • 6gg5 - hPyK M2 muscle + tryptophan
    
  • 6gg6 - hPyK M2 muscle + serine
    
  • 6nub - hPyK M2 muscle (mutant) + serine
    
  • 6nu1 - hPyK M2 muscle + cysteine
    
  • 6nu5 - hPyK M2 muscle (mutant) + cysteine
    
  • 6ttf, 6tti, 6ttq - hPyK M2 muscle + inhibitor – Cryo EM
    
  • 6tth - hPyK M2 muscle + threonine – Cryo EM
    
  • 6v74, 6v75 - hPyK M2 muscle + asparagine
    
  • 6v76 - hPyK M2 muscle + valine
    
  • 8g2e, 9iqq, 9o3b - hPyK M2 muscle + activator
    
  • 8f5u - rPyK muscle + pyruvate
    
• Pyruvate kinase muscle higher complexes
  • 3me3 – hPyK M1/M2 muscle + aniline derivative + fructose bisphosphate
    
  • 4g1n - hPyK M1/M2 muscle + pyridazine derivative + oxalate
    
  • 3h6o - hPyK M1/M2 muscle + pyridazine derivative + fructose bisphosphate
    
  • 3gqy, 3gr4, 3u2z - hPyK M1/M2 muscle + piperazine derivative + fructose bisphosphate
    
  • 8hmq, 8hmr, 8hms, 8hmu - hPyK muscle (mutant) + Pi + fructose bisphosphate
    
  • 5x0i - hPyK M2 muscle (mutant) + serine + fructose bisphosphate
    
  • 7l21 - hPyK M2 muscle (mutant) + oxalate + fructose bisphosphate
    
  • 6jfb - hPyK M2 muscle + serine + phosphate
    
  • 5x1v, 5x1w - hPyK M2 muscle + activator + fructose bisphosphate
    
  • 4jpg - hPyK M1/M2 muscle + pyrimidine derivative +fructosebisphosphate
    
  • 3srd - hPyK M1/M2 muscle + oxalate + fructose bisphosphate
    
  • 4fxf - hPyK M1/M2 muscle + oxalate + ATP + fructose bisphosphate
    
  • 3n25 – rPyK M1/M2 muscle + proline + Mn + pyruvate
    
  • 2g50 - rPyK M1/M2 muscle + alanine + Mn + pyruvate
    
  • 8f6m - rPyK muscle + Ala + Mn + ADP
    
  • 1pkn - rPyK muscle + Mn + pyruvate
    
  • 1aqf – rPyK muscle + Mg + phospholactate
    
  • 1a49, 1a5u - rPyK muscle + ATP + oxalate
    
• Pyruvate kinase liver or erythrocyte pyruvate kinase

• • 9vxp - hPyK liver – Cryo EM
    
  • 2vgb – hPyK liver
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  • 2vgf, 2vgg, 2vgi 6nn5, 6nn7, 6nn8, 7qdn – hPyK liver (mutant)
    
  • 9w4q, 9w7y, 9w81 - hPyK liver + activator – Cryo EM
    
  • 8tbs, 8tbt, 8tbu - hPyK liver + activator
    
  • 7fs7 - hPyK liver + modulator
    
  • 9wdo, 9wdq, 9wdr, 9edt - hPyK liver + drug – Cryo EM
    
  • 8xfd - hPyK liver + activator
    
  • 9r3h, 9r3i, 9r3l, 9r3m, 9r3o, 9rdf, 9rfq, 9rft - hPyK liver + fluorescent probe
    
  • 9wez - hPyK liver + fructose bisphosphate – Cryo EM
    
  • 6nn4 - hPyK M2 liver (mutant) + fructose bisphosphate
    
  • 6ech, 6eck - PyK liver + fructose bisphosphate - rat
    
  • 5sc8, 5sc9, 5sca, 5scb, 5scc, 5scd, 5sce, 5scf, 5scg, 5sch, 5sci, 5scj, 5sck, 5scl, 5sdt, 7qzu - hPyK liver + anthracene derivative + fructose bisphosphate
    
  • 7frv, 7frw, 7frx, 7fry, 7frz, 7fs0, 7fs1, 7fs2, 7fs3, 7fs4, 7fs5, 7fs6, 7fs8, 7fs9, 7fsa, 7fsb, 7fsc, 7fsd - hPyK liver + modulator + fructose bisphosphate
    
  • 4ima, 4ip7 - hPyK liver (mutant) + citrate + adenosine + fructose bisphosphate
    
• Pyruvate kinase
  • 6du6 – PyK - mosquito
    
  • 1pky, 4yng, 6k0k – EcPyK - Eschericia coli
    
  • 1e0t, 1e0u, 8edq, 8edr, 8eds, 8edt, 8eq0, 8eq1, 8eq3, 8eu4 - EcPyK (mutant)
    
  • 3t05, 3t0t – SaPyK – Staphylococcus aureus
    
  • 3qtg – PyK – Pyrobaculum aerophilum
    
  • 4krz – TcPyK – Trypanosoma cruzei
    
  • 5wrp - MtPyK – Mycobacterium tuberculosis
    
  • 1pkl, 3e0w, 3hqn – LmPyK – Leishmania mexicana
    
  • 3khd, 7z4m – PfPyK – Plasmodium falciparum
    
  • 7z4q, 7z4r - PfPyK (mutant)
    
  • 3eoe, 3gg8 – PyK – Toxoplasma gondii
    
  • 3ma8, 4drs – CpPyK – Cryptosporidium parvum
    
  • 2e28 - PyK (mutant) – Geobacillus stearothermophilus
    
  • 7oo1 – PaPyK – Pseudomonas aeruginosa
    
  • 7ueh – PyK – Zymomonas mobilis
    
  • 8ias - SpPyK – Streptococcus pneumoniae
    
  • 8iw2 - PyK – Entamoeba histolytica

• Pyruvate kinase binary complex
  • 8x4r – hPyK + Phe
    
  • 3qv9 – TcPyK + Ponceau S
    
  • 3qv6 – LmPyK + acid blue 80
    
  • 3e0v – LmPyK + sulfate
    
  • 3hqq - LmPyK + fructose bisphosphate
    
  • 3qv8 – LmPyK + benzothiazole
    
  • 3pp7 – LmPyK + suramin
    
  • 3is4, 3ktx – LmPyK + pyrenetetrasulfonic acid
    
  • 3t07 – SaPyK + bis-indole alkaloid
    
  • 4hyw – TbPyK + fructose bisphosphate – Trypanosoma brucei
    
  • 6su1, 6su2 – PyK + citrate – Trypanosoma congolense
    
  • 5ws8 - MtPyK + oxalate
    
  • 6p0y - CpPyK + ADP
    
  • 8iav - SpPyK + fructose bisphosphate
    
  • 8iat - SpPyK + oxalate
    
  • 8iaw - SpPyK + phosphoenolpyruvate
    
  • 7z4n -PfPyK + pyruvate
    
  • 8rtf, 8rvr -PyK + antibody – Trypanosoma congolense
    
• Pyruvate kinase higher complexes
  • 8xfd – hPyK + activator + fructose bisphosphate
    
  • 1a3w – yPyK + Mn + phosphoglycolic acid + fructose bisphosphate – yeast
    
  • 1a3x - yPyK + Mn + phosphoglycolic acid
    
  • 4hyv – TbPyK + phosphoenolpyruvate + fructose bisphosphate
    
  • 4kct – TbPyK + pyruvate + fructose bisphosphate
    
  • 4kcu – TbPyK + malate + fructose bisphosphate
    
  • 4kcv – TbPyK + oxoglutarate + fructose bisphosphate
    
  • 4kcw – TbPyK + oxalate + fructose bisphosphate
    
  • 4ks0 – TcPyK + oxalate + fructose bisphosphate
    
  • 5ws9 – MtPyK + oxalate + AMP + ATP
    
  • 5wsa – MtPyK + oxalate + glucose-6-phosphate
    
  • 5wsb, 5wsc – MtPyK + oxalate + glucose-6-phosphate + AMP
    
  • 6ito – MtPyK + oxalate + ribose-5-phosphate + AMP
    
  • 3hqo – LmPyK + ATP + oxalate
    
  • 3hqp - LmPyK + ATP + oxalate + fructose bisphosphate
    
  • 3qv7 – LmPyK + acid blue 25 + Ponceau S
    
  • 3srk – LmPyK + saccharine + inhibitor
    
  • 6qxl – PaPyK + malonate + glucose-6-phosphate + Mg
    
  • 6ksh – PfPyK + oxalate + ATP
    
  • 8iax - SpPyK + fructose bisphosphate + phosphoenolpyruvate
    
  • 8iau - SpPyK + fructose bisphosphate + oxalate
    
  • 8xw6, 8xw7, 8xw8, 8xw9, 8zly - SpPyK + fructose bisphosphate + oxalate + nucleotide
    

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