1tip | pdb_00001tip
THE BISPHOSPHATASE DOMAIN OF THE BIFUNCTIONAL RAT LIVER 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE
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Overview
The crystal structure of the fructose-2,6-bisphosphatase domain trapped, during the reaction reveal a phosphorylated His 258, and a water molecule, immobilized by the product, fructose-6-phosphate. The geometry suggests, that the dephosphorylation step requires prior removal of the product for, an 'associative in-line' phosphoryl transfer to the catalytic water.
About this Structure
1TIP is a Single protein structure of sequence from Rattus norvegicus with F6P as ligand. Active as Fructose-2,6-bisphosphate 2-phosphatase, with EC number 3.1.3.46 Full crystallographic information is available from OCA.
Reference
Crystal structure of a trapped phosphoenzyme during a catalytic reaction., Lee YH, Olson TW, Ogata CM, Levitt DG, Banaszak LJ, Lange AJ, Nat Struct Biol. 1997 Aug;4(8):615-8. PMID:9253407
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