User:Daniel Seeman/Alpha-1-antitrypsin

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D load='1atu' size='350' frame='false' scene=
1atu, resolution 2.70Å (default scene)
Structural annotation: Resources: CATH : 1Atu002, 1Atu001 InterPro : Ipr000215 Pfam : PF00079 SCOP : d1atu__ UniProt : P01009
Functional annotation: Cellular component: extracellular space extracellular region Biological process: acute-phase response Molecular function: protein binding serine-type endopeptidase inhibitor activity endopeptidase inhibitor activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Alpha-1-antitrypsin (or α1-antitrypsin, A1AT) is an inhibitor of trypsin. It is a member of the Serine Protease Inhibitor (Serpin) family, and as such undergoes a conformational change where a loop region becomes ordered as a Beta Strand. In this case trypsin is inhibited when a covalent bond is formed to A1AT.

See Also

• 1atu
• 1ezx

Proteopedia Page Contributors and Editors (what is this?)

Daniel Seeman