5ijd

The crystal structure of mouse TLR4/MD-2/lipid A complex

spinqualitylabelsall models 5ijd, resolution 2.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5ijd is a 4 chain structure with sequence from Eptatretus burgeri and Mus musculus. This structure supersedes the now removed PDB entry 5hg6. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.7Å Ligands: DAO, LP4, LP5, MYR, NAG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease TLR4_MOUSE Note=The protein is encoded by the Lps locus, an important susceptibility locus, influencing the propensity to develop a disseminated Gram-negative infection. Function Q4G1L2_EPTBU TLR4_MOUSE Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). See Also Toll-like Receptor 3D structures Variable lymphocyte receptor 3D structures

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