4r6u

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IL-18 receptor complex

Structural highlights

4r6u is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.8Å
Ligands:NAG
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

IL18R_HUMAN Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.

Publication Abstract from PubMed

Interleukin 18 (IL-18), a member of the IL-1 family of cytokines, is an important regulator of innate and acquired immune responses. It signals through its ligand-binding primary receptor IL-18Ralpha and accessory receptor IL-18Rbeta. Here we report the crystal structure of IL-18 with the ectodomain of IL-18Ralpha, which reveals the structural basis for their specific recognition. It confirms that surface charge complementarity determines the ligand-binding specificity of primary receptors in the IL-1 receptor family. We suggest that IL-18 signaling complex adopts an architecture similar to other agonistic cytokines and propose a general ligand-receptor assembly and activation model for the IL-1 family.

Structural basis for the specific recognition of IL-18 by its alpha receptor.,Wei H, Wang D, Qian Y, Liu X, Fan S, Yin HS, Wang X FEBS Lett. 2014 Sep 26. pii: S0014-5793(14)00696-6. doi:, 10.1016/j.febslet.2014.09.019. PMID:25261253[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
3 reviews cite this structure
The modern interleukin-1 superfamily: Divergent roles in obesity.
Lee et al. (2016)
2 more
9 other articles
No citations found

See Also

References

  1. ↑ Wei H, Wang D, Qian Y, Liu X, Fan S, Yin HS, Wang X. Structural basis for the specific recognition of IL-18 by its alpha receptor. FEBS Lett. 2014 Sep 26. pii: S0014-5793(14)00696-6. doi:, 10.1016/j.febslet.2014.09.019. PMID:25261253 doi:http://dx.doi.org/10.1016/j.febslet.2014.09.019

Contents


PDB ID 4r6u

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OCA

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