1cg5

From Proteopedia

DEOXY FORM HEMOGLOBIN FROM DASYATIS AKAJEI

PDB ID 1cg5

Drag the structure with the mouse to rotate

Structural highlights

1cg5 is a 2 chain structure with sequence from Hemitrygon akajei. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.6Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HBA_HEMAK

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The three-dimensional structures of the deoxy- and carbonmonoxyhaemoglobin (Hb) from Dasyatis akajei, a stingray, have been determined at 1.6 and 1.9 A resolution, respectively. This is one of the most distantly related vertebrate Hbs to human HbA. Both structures resemble the respective forms of HbA, indicating that the alpha2beta2-type tetramer and the mode of the quaternary structure change are common to Hbs of jawed vertebrates. Larger deviations between D. akajei Hb and human HbA are observed in various parts of the molecule, even in the E and F helices. Significant mutations and/or conformational changes are also observed around the haems, in the C-terminal region of the beta subunit, in the alpha1beta2 interface and in the organic phosphate-binding site of HbA. Despite these structural differences, the oxygen affinity, haem-haem interaction, Bohr effect and organic phosphate effect of D. akajei Hb are all only moderately reduced. Compared with human HbA, the overall r.m.s. deviation of main-chain atoms in the helical regions of bony fish Hbs is smaller than that of D. akajei Hb.

Structures of the deoxy and CO forms of haemoglobin from Dasyatis akajei, a cartilaginous fish.,Chong KT, Miyazaki G, Morimoto H, Oda Y, Park SY Acta Crystallogr D Biol Crystallogr. 1999 Jul;55(Pt 7):1291-300. PMID:10393295^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Chong KT, Miyazaki G, Morimoto H, Oda Y, Park SY. Structures of the deoxy and CO forms of haemoglobin from Dasyatis akajei, a cartilaginous fish. Acta Crystallogr D Biol Crystallogr. 1999 Jul;55(Pt 7):1291-300. PMID:10393295