Structural highlights
Function
YBAK_HAEIN Functions in trans to edit the amino acid from incorrectly charged Cys-tRNA(Pro) via a Cys-tRNA(Pro) deacylase activity. Probably compensates for the lack of Cys-tRNA(Pro) editing by ProRS. Is also able to deacylate Cys-tRNA(Cys), and displays weak deacylase activity in vitro against Gly-tRNA(Gly), as well as, at higher concentrations, some other correctly charged tRNAs. Does not cleave Pro-tRNA(Pro).[1] [2] [3]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ An S, Musier-Forsyth K. Trans-editing of Cys-tRNAPro by Haemophilus influenzae YbaK protein. J Biol Chem. 2004 Oct 8;279(41):42359-62. Epub 2004 Aug 20. PMID:15322138 doi:http://dx.doi.org/10.1074/jbc.C400304200
- ↑ Ruan B, Soll D. The bacterial YbaK protein is a Cys-tRNAPro and Cys-tRNA Cys deacylase. J Biol Chem. 2005 Jul 8;280(27):25887-91. Epub 2005 May 10. PMID:15886196 doi:http://dx.doi.org/10.1074/jbc.M502174200
- ↑ So BR, An S, Kumar S, Das M, Turner DA, Hadad CM, Musier-Forsyth K. Substrate-mediated fidelity mechanism ensures accurate decoding of proline codons. J Biol Chem. 2011 Sep 9;286(36):31810-20. doi: 10.1074/jbc.M111.232611. Epub 2011, Jul 18. PMID:21768119 doi:http://dx.doi.org/10.1074/jbc.M111.232611
