1f75

Structural highlights

Function

UPPS_MICLU Generates ditrans,octacis-undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP) and farnesyl diphosphate. UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Undecaprenyl pyrophosphate synthase

References

1. ↑ Shimizu N, Koyama T, Ogura K. Molecular cloning, expression, and purification of undecaprenyl diphosphate synthase. No sequence similarity between E- and Z-prenyl diphosphate synthases. J Biol Chem. 1998 Jul 31;273(31):19476-81. PMID:9677368
2. ↑ Koyama T, Yoshida I, Ogura K. Undecaprenyl diphosphate synthase from Micrococcus luteus B-P 26: essential factors for the enzymatic activity. J Biochem. 1988 May;103(5):867-71. PMID:3182755