Structural highlights
Function
HEPT_HAEIN Probable toxic component of a type VII toxin-antitoxin (TA) system, probably an RNase. Neutralized by cognate antitoxin MntA. Neutralization is probably due to AMPylation by MntA (Probable). A mixture of HepT and MntA binds nucleotides; the highest affinity is for TTP, ATP binds more tightly than ADP or AMP (PubMed:16028221).[1] [2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Lehmann C, Pullalarevu S, Krajewski W, Willis MA, Galkin A, Howard A, Herzberg O. Structure of HI0073 from Haemophilus influenzae, the nucleotide-binding domain of a two-protein nucleotidyl transferase. Proteins. 2005 Sep 1;60(4):807-11. PMID:16028221 doi:http://dx.doi.org/10.1002/prot.20586
- ↑ Jia X, Yao J, Gao Z, Liu G, Dong YH, Wang X, Zhang H. Structure-function analyses reveal the molecular architecture and neutralization mechanism of a bacterial HEPN-MNT toxin-antitoxin system. J Biol Chem. 2018 May 4;293(18):6812-6823. doi: 10.1074/jbc.RA118.002421. Epub, 2018 Mar 19. PMID:29555683 doi:http://dx.doi.org/10.1074/jbc.RA118.002421
