First time at Proteopedia? Click on the green links: they change the 3D image. Click and drag the molecules. Proteopedia is a 3D, interactive encyclopedia of proteins, RNA, DNA and other molecules. With a free user account, you can edit pages in Proteopedia. Visit the Main Page to learn more.

1jv2

From Proteopedia

Jump to: navigation, search
1jv2, resolution 3.10Å ()
Ligands: , ,
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml


Contents

CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHAVBETA3

Publication Abstract from PubMed

Integrins are alphabeta heterodimeric receptors that mediate divalent cation-dependent cell-cell and cell-matrix adhesion through tightly regulated interactions with ligands. We have solved the crystal structure of the extracellular portion of integrin alphaVbeta3 at 3.1 A resolution. Its 12 domains assemble into an ovoid "head" and two "tails." In the crystal, alphaVbeta3 is severely bent at a defined region in its tails, reflecting an unusual flexibility that may be linked to integrin regulation. The main inter-subunit interface lies within the head, between a seven-bladed beta-propeller from alphaV and an A domain from beta3, and bears a striking resemblance to the Galpha/Gbeta interface in G proteins. A metal ion-dependent adhesion site (MIDAS) in the betaA domain is positioned to participate in a ligand-binding interface formed of loops from the propeller and betaA domains. MIDAS lies adjacent to a calcium-binding site with a potential regulatory function.

Crystal structure of the extracellular segment of integrin alpha Vbeta3., Xiong JP, Stehle T, Diefenbach B, Zhang R, Dunker R, Scott DL, Joachimiak A, Goodman SL, Arnaout MA, Science. 2001 Oct 12;294(5541):339-45. Epub 2001 Sep 6. PMID:11546839

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

1jv2 is a 2 chain structure with sequence from Homo sapiens. The February 2011 RCSB PDB Molecule of the Month feature on Integrin by David Goodsell is 10.2210/rcsb_pdb/mom_2011_2. Full crystallographic information is available from OCA.

See Also

Reference

  • Xiong JP, Stehle T, Diefenbach B, Zhang R, Dunker R, Scott DL, Joachimiak A, Goodman SL, Arnaout MA. Crystal structure of the extracellular segment of integrin alpha Vbeta3. Science. 2001 Oct 12;294(5541):339-45. Epub 2001 Sep 6. PMID:11546839 doi:10.1126/science.1064535

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools