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1m6b
From Proteopedia
| 1m6b, resolution 2.60Å () | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Sites: | , , , , , , , , , , , , , , , , and | ||||||||
| Ligands: | , , | ||||||||
| Activity: | Receptor protein-tyrosine kinase, with EC number 2.7.10.1 | ||||||||
| Domains: | Recep_L_domain, FU, FU, Furin-like | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Structure of the HER3 (ERBB3) Extracellular Domain
We have determined the 2.6 angstrom crystal structure of the entire extracellular region of human HER3 (ErbB3), a member of the epidermal growth factor receptor (EGFR) family. The structure consists of four domains with structural homology to domains found in the type I insulin-like growth factor receptor. The HER3 structure reveals a contact between domains II and IV that constrains the relative orientations of ligand-binding domains and provides a structural basis for understanding both multiple-affinity forms of EGFRs and conformational changes induced in the receptor by ligand binding during signaling. These results also suggest new therapeutic approaches to modulating the behavior of members of the EGFR family.
Structure of the extracellular region of HER3 reveals an interdomain tether., Cho HS, Leahy DJ, Science. 2002 Aug 23;297(5585):1330-3. Epub 2002 Aug 1. PMID:12154198
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1M6B is a 2 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Cho HS, Leahy DJ. Structure of the extracellular region of HER3 reveals an interdomain tether. Science. 2002 Aug 23;297(5585):1330-3. Epub 2002 Aug 1. PMID:12154198 doi:10.1126/science.1074611
Page seeded by OCA on Wed Mar 31 12:52:23 2010
