1ml0

From Proteopedia

Jump to: navigation, search


1ml0, resolution 2.80Å ()
Gene: M3 (Murid herpesvirus 4), MONOCYTE CHEMOATTRACTANT PROTEIN 1 (Homo sapiens)
Related: 1mkf, 1dok
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Contents

VIRAL CHEMOKINE BINDING PROTEIN M3 FROM MURINE GAMMAHERPESVIRUS68 IN COMPLEX WITH THE P8A VARIANT OF CC-CHEMOKINE MCP-1

Publication Abstract from PubMed

The M3 protein encoded by murine gamma herpesvirus68 (gamma HV68) functions as an immune system saboteur by the engagement of chemoattractant cytokines, thereby altering host antiviral inflammatory responses. Here we report the crystal structures of M3 both alone and in complex with the CC chemokine MCP-1. M3 is a two-domain beta sandwich protein with a unique sequence and topology, forming a tightly packed anti-parallel dimer. The stoichiometry of the MCP-1:M3 complex is 2:2, with two monomeric chemokines embedded at distal ends of the preassociated M3 dimer. Conformational flexibility and electrostatic complementation are both used by M3 to achieve high-affinity and broad-spectrum chemokine engagement. M3 also employs structural mimicry to promiscuously sequester chemokines, engaging conservative structural elements associated with both chemokine homodimerization and binding to G protein-coupled receptors.

Structural basis of chemokine sequestration by a herpesvirus decoy receptor., Alexander JM, Nelson CA, van Berkel V, Lau EK, Studts JM, Brett TJ, Speck SH, Handel TM, Virgin HW, Fremont DH, Cell. 2002 Nov 1;111(3):343-56. PMID:12419245

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

1ml0 is a 2 chain structure with sequence from Homo sapiens and Murid herpesvirus 4. Full crystallographic information is available from OCA.

See Also

Reference

  • Alexander JM, Nelson CA, van Berkel V, Lau EK, Studts JM, Brett TJ, Speck SH, Handel TM, Virgin HW, Fremont DH. Structural basis of chemokine sequestration by a herpesvirus decoy receptor. Cell. 2002 Nov 1;111(3):343-56. PMID:12419245

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools