1p4x

Structural highlights

Function

SARS_STAA8 Transcriptional regulator that controls expression of some virulence factors in a cell density-dependent manner. Acts as an activator of the gene encoding protein A (spa). Negatively regulates the expression of alpha-hemolysin (hla).^{[1] [2]}

References

1. ↑ Tegmark K, Karlsson A, Arvidson S. Identification and characterization of SarH1, a new global regulator of virulence gene expression in Staphylococcus aureus. Mol Microbiol. 2000 Jul;37(2):398-409. PMID:10931334 doi:10.1046/j.1365-2958.2000.02003.x
2. ↑ Cheung AL, Schmidt K, Bateman B, Manna AC. SarS, a SarA homolog repressible by agr, is an activator of protein A synthesis in Staphylococcus aureus. Infect Immun. 2001 Apr;69(4):2448-55. PMID:11254606 doi:10.1128/IAI.69.4.2448-2455.2001