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1rz4, resolution 2.10Å ()
Non-Standard Residues:
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml


Crystal Structure of Human eIF3k

Publication Abstract from PubMed

eIF3k, the smallest subunit of eukaryotic initiation factor 3 (eIF3), interacts with several other subunits of eIF3 and the 40 S ribosomal subunit. eIF3k is conserved among high eukaryotes, including mammals, insects, and plants, and it is ubiquitously expressed in human tissues. Interestingly, eIF3k does not exist in some species of yeast. Thus, eIF3k may play a unique regulatory role in higher organisms. Here we report the crystal structure of human eIF3k, the first high-resolution structure of an eIF3 component. This novel structure contains two distinct domains, a HEAT (named for Huntington, elongation factor 3, A subunit of protein phosphatase 2A, target of rapamycin) repeat-like HAM (HEAT analogous motif) domain and a winged-helix-like WH domain. Through structural comparison and sequence conservation analysis, we show that eIF3k has three putative protein-binding surfaces and has potential RNA binding activity. The structure provides key information for understanding the structure and function of the eIF3 complex.

Crystal structure of human eIF3k, the first structure of eIF3 subunits., Wei Z, Zhang P, Zhou Z, Cheng Z, Wan M, Gong W, J Biol Chem. 2004 Aug 13;279(33):34983-90. Epub 2004 Jun 4. PMID:15180986

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

1rz4 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

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