1su2

Structural highlights

Function

Y1025_DEIRA Hydrolase that can act as a nucleoside triphosphatase and a dinucleoside polyphosphate pyrophosphatase. The best substrates are 8-oxo-dGTP and 8-oxo-GTP. Other substrates include Ap4A, dGTP and GTP. May be involved in protection from damage caused by radiation.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Nudix hydrolase
• Nudix hydrolase 3D structures
• 7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures

References

1. ↑ Xu A, Desai AM, Brenner SE, Kirsch JF. A continuous fluorescence assay for the characterization of Nudix hydrolases. Anal Biochem. 2013 Jun 15;437(2):178-84. PMID:23481913 doi:10.1016/j.ab.2013.02.023