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1sum
From Proteopedia
| 1sum, resolution 2.00Å () | |||||||||
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| Ligands: | , , , | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum, TOPSAN | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Crystal structure of a hypothetical protein at 2.0 A resolution
PhoU proteins are known to play a role in the regulation of phosphate uptake. In Thermotoga maritima, two PhoU homologues have been identified bioinformatically. Here we report the crystal structure of one of the PhoU homologues at 2.0 A resolution. The structure of the PhoU protein homologue contains a highly symmetric new structural fold composed of two repeats of a three-helix bundle. The structure unexpectedly revealed a trinuclear and a tetranuclear iron cluster that were found to be bound on the surface. Each of the two multinuclear iron clusters is coordinated by a conserved E(D)XXXD motif pair. Our structure reveals a new class of metalloprotein containing multinuclear iron clusters. The possible functional implication based on the structure are discussed.
Crystal structure of a PhoU protein homologue: a new class of metalloprotein containing multinuclear iron clusters., Liu J, Lou Y, Yokota H, Adams PD, Kim R, Kim SH, J Biol Chem. 2005 Apr 22;280(16):15960-6. Epub 2005 Feb 16. PMID:15716271
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1sum is a 1 chain structure with sequence from Thermotoga maritima. Full crystallographic information is available from OCA.
Reference
- Liu J, Lou Y, Yokota H, Adams PD, Kim R, Kim SH. Crystal structure of a PhoU protein homologue: a new class of metalloprotein containing multinuclear iron clusters. J Biol Chem. 2005 Apr 22;280(16):15960-6. Epub 2005 Feb 16. PMID:15716271 doi:10.1074/jbc.M414117200
Categories: Thermotoga maritima | Adams, P D. | BSGC, Berkeley Structural Genomics Center. | Kim, R. | Kim, S H. | Liu, J. | Lou, Y. | Yokota, H. | Abc transport | Berkeley structural genomics center | Bsgc | Phou | Protein structure initiative | Psi | Pst | Structural genomic | Structure funded by nih | Transport protein
