First time at Proteopedia? Click on the green links, they change the 3D image. Click and drag the molecules. Proteopedia is a 3D, interactive encyclopedia of proteins, RNA, DNA and other molecules. With a free user account, you can edit pages in Proteopedia. Visit the Main Page to learn more.

1uk0

From Proteopedia

Jump to: navigation, search

This article has been automatically seeded. You can help Proteopedia by expanding it.

1uk0, resolution 3.00Å ()

Ligands:

Activity:

NAD(+) ADP-ribosyltransferase, with EC number 2.4.2.30

Domains:

parp_like

Related:

1uk1

Structural annotation:
Resources:	CATH : 1Uk0A02, 1Uk0A01, 1Uk0B02, 1Uk0B01 InterPro : Ipr012982, Ipr012317, Ipr001290, Ipr004102, Ipr008288, Ipr001357, Ipr001510, Ipr008893 Pfam : PF00644, PF02877 SCOP : d1uk0a2, d1uk0a1, d1uk0b2, d1uk0b1 UniProt : P09874

Functional annotation:
Resources:	GeneCard : PARP1
Cellular component:	nuclear envelope nucleus intracellular nucleolus
Biological process:	transcription from RNA polymerase II promoter protein amino acid ADP-ribosylation response to DNA damage stimulus DNA repair
Molecular function:	transferase activity metal ion binding NAD+ ADP-ribosyltransferase activity zinc ion binding DNA binding protein binding transferase activity, transferring glycosyl groups NAD binding identical protein binding

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, PDBsum, RCSB

Coordinates:

save as pdb, mmCIF, xml

Crystal structure of catalytic domain of human poly(ADP-ribose) polymerase with a novel inhibitor

Publication Abstract from PubMed

The crystal structure of human recombinant poly(ADP-ribose) polymerase (PARP) complexed with a potent inhibitor, FR257517, was solved at 3.0 A resolution. The fluorophenyl part of the inhibitor induces an amazing conformational change in the active site of PARP by motion of the side chain of the amino acid, Arg878, which forms the bottom of the active site. Consequently, a corn-shaped hydrophobic subsite, which consists of the side chains of Leu769, Ile879, Pro881, and the methylene chain of Arg878, newly emerges from the well-known active site.

Inhibitor-induced structural change of the active site of human poly(ADP-ribose) polymerase., Kinoshita T, Nakanishi I, Warizaya M, Iwashita A, Kido Y, Hattori K, Fujii T, FEBS Lett. 2004 Jan 2;556(1-3):43-6. PMID:14706823

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

1UK0 is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Kinoshita T, Nakanishi I, Warizaya M, Iwashita A, Kido Y, Hattori K, Fujii T. Inhibitor-induced structural change of the active site of human poly(ADP-ribose) polymerase. FEBS Lett. 2004 Jan 2;556(1-3):43-6. PMID:14706823

Page seeded by OCA on Wed Feb 18 08:26:46 2009