Structural highlights
Function
RICE2_ARATH 3'-to-5' exoribonuclease (RNase) specifically targeting single-stranded RNAs (PubMed:28463111). Triggers miRNA accumulation in RNA-induced silencing complex (RISC), composed of miRNAs and AGO proteins, by degrading uridylated cleavage fragments (PubMed:28463111). Required during plant growth and development (By similarity).[UniProtKB:Q9SF21][1]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Zhang Z, Hu F, Sung MW, Shu C, Castillo-Gonzalez C, Koiwa H, Tang G, Dickman M, Li P, Zhang X. RISC-interacting clearing 3'- 5' exoribonucleases (RICEs) degrade uridylated cleavage fragments to maintain functional RISC in Arabidopsis thaliana. Elife. 2017 May 2;6. pii: e24466. doi: 10.7554/eLife.24466. PMID:28463111 doi:http://dx.doi.org/10.7554/eLife.24466
