Structure of the Tim14-Tim16 complex of the mitochondrial protein import motor
Structural highlights
2guz is a 16 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
TIM14_YEAST Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to stimulate activity of mtHSP70 (SSC1).[1][2][3]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
↑ Mokranjac D, Sichting M, Neupert W, Hell K. Tim14, a novel key component of the import motor of the TIM23 protein translocase of mitochondria. EMBO J. 2003 Oct 1;22(19):4945-56. PMID:14517234 doi:http://dx.doi.org/10.1093/emboj/cdg485
↑ Truscott KN, Voos W, Frazier AE, Lind M, Li Y, Geissler A, Dudek J, Muller H, Sickmann A, Meyer HE, Meisinger C, Guiard B, Rehling P, Pfanner N. A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria. J Cell Biol. 2003 Nov 24;163(4):707-13. PMID:14638855 doi:http://dx.doi.org/10.1083/jcb.200308004
↑ D'Silva PD, Schilke B, Walter W, Andrew A, Craig EA. J protein cochaperone of the mitochondrial inner membrane required for protein import into the mitochondrial matrix. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13839-44. Epub 2003 Nov 6. PMID:14605210 doi:http://dx.doi.org/10.1073/pnas.1936150100
