2hxd

Structural highlights

Function

DCDB_METJA Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. It also acts as a dUTP diphosphatase with a lower affinity for dUTP than for dCTP.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Deaminase 3D structures

References

1. ↑ Li H, Xu H, Graham DE, White RH. The Methanococcus jannaschii dCTP deaminase is a bifunctional deaminase and diphosphatase. J Biol Chem. 2003 Mar 28;278(13):11100-6. PMID:12538648 doi:10.1074/jbc.M212460200
2. ↑ Bjornberg O, Neuhard J, Nyman PO. A bifunctional dCTP deaminase-dUTP nucleotidohydrolase from the hyperthermophilic archaeon Methanocaldococcus jannaschii. J Biol Chem. 2003 Jun 6;278(23):20667-72. Epub 2003 Mar 31. PMID:12670946 doi:10.1074/jbc.M213010200