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2nnq

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2nnq, resolution 1.80Å ()

Ligands:

Gene:

FABP4 (Homo sapiens)

Domains:

Lipocalin

Structural annotation:
Resources:	InterPro : Ipr000566, Ipr011038, Ipr000463, Ipr012674 Pfam : PF00061 UniProt : P15090

Functional annotation:
Resources:	GeneCard : FABP4
Cellular component:	cytoplasm soluble fraction
Biological process:	cytokine production negative regulation of protein kinase activity transport positive regulation of inflammatory response negative regulation of transcription cholesterol homeostasis
Molecular function:	lipid binding protein binding binding transcription repressor activity fatty acid binding transporter activity

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, PDBsum, RCSB

Coordinates:

save as pdb, mmCIF, xml

Crystal structure of human adipocyte fatty acid binding protein in complex with ((2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-3-biphenylyl)oxy)acetic acid

Publication Abstract from PubMed

Herein we report the first disclosure of biphenyl azoles that are nanomolar binders of adipocyte fatty acid binding protein (aFABP or aP2) with up to thousand-fold selectivity against muscle fatty acid binding protein and epidermal fatty acid binding protein. In addition a new radio-ligand to determine binding against the three fatty acid binding proteins was also synthesized.

Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP)., Sulsky R, Magnin DR, Huang Y, Simpkins L, Taunk P, Patel M, Zhu Y, Stouch TR, Bassolino-Klimas D, Parker R, Harrity T, Stoffel R, Taylor DS, Lavoie TB, Kish K, Jacobson BL, Sheriff S, Adam LP, Ewing WR, Robl JA, Bioorg Med Chem Lett. 2007 Jun 15;17(12):3511-5. Epub 2006 Dec 21. PMID:17502136

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

2NNQ is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Sulsky R, Magnin DR, Huang Y, Simpkins L, Taunk P, Patel M, Zhu Y, Stouch TR, Bassolino-Klimas D, Parker R, Harrity T, Stoffel R, Taylor DS, Lavoie TB, Kish K, Jacobson BL, Sheriff S, Adam LP, Ewing WR, Robl JA. Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP). Bioorg Med Chem Lett. 2007 Jun 15;17(12):3511-5. Epub 2006 Dec 21. PMID:17502136

Page seeded by OCA on Wed Feb 18 01:56:28 2009