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2oit
From Proteopedia
| 2oit, resolution 1.65Å () | |||||||||
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| Ligands: | |||||||||
| Gene: | NUP214 (Homo sapiens) | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Contents |
Crystal Structure of the N-terminal Domain of the Human Proto-oncogene Nup214/CAN
The mammalian nuclear pore complex (NPC) is an approximately 120-MDa proteinaceous assembly consisting of approximately 30 proteins and is the sole gate in the nuclear envelope. The human protooncogene Nup214 was first identified as a target for chromosomal translocation involved in leukemogenesis. Nup214 is located on the cytoplasmic face of the NPC and is implicated in anchoring the cytoplasmic filaments of the NPC and recruiting the RNA helicase Ddx19. Here, we present the crystal structure of the human Nup214 N-terminal domain at 1.65-A resolution. The structure reveals a seven-bladed beta-propeller followed by a 30-residue C-terminal extended peptide segment, which folds back onto the beta-propeller and binds to its bottom face. The beta-propeller repeats lack any recognizable sequence motif and are distinguished by extensive insertions between the canonical beta-strands. We propose a mechanism by which the C-terminal peptide extension is involved in NPC assembly.
Crystal structure of the N-terminal domain of the human protooncogene Nup214/CAN., Napetschnig J, Blobel G, Hoelz A, Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1783-8. Epub 2007 Jan 30. PMID:17264208
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
Disease
Known disease associated with this structure: Leukemia, T-cell acute lymphoblastic OMIM:[114350], Leukemia, acute myeloid OMIM:[114350]
About this Structure
2OIT is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA. Relevant biological numbers for this protein at B10NUMB3R5
Reference
- Napetschnig J, Blobel G, Hoelz A. Crystal structure of the N-terminal domain of the human protooncogene Nup214/CAN. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1783-8. Epub 2007 Jan 30. PMID:17264208
Page seeded by OCA on Mon May 25 07:55:55 2009
