First time at Proteopedia? Click on the green links: they change the 3D image. Click and drag the molecules. Proteopedia is a 3D, interactive encyclopedia of proteins, RNA, DNA and other molecules. With a free user account, you can edit pages in Proteopedia. Visit the Main Page to learn more.

2wbj

From Proteopedia

Jump to: navigation, search


2wbj, resolution 3.00Å ()
Ligands: , , ,
Related: 1kg0, 1d6e, 1bx2, 1d5m, 1lo5, 1hxy, 1seb, 1jws, 1h15, 1hqr, 2seb, 1fv1, 1sjh, 1jwm, 1fyt, 1klu, 1ymm, 1j8h, 1zgl, 1t5w, 1d5x, 1klg, 2g9h, 1aqd, 1dlh, 1sje, 1d5z, 1jwu, 1t5x, 1a6a
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Contents

TCR complex

Publication Abstract from PubMed

Environmental factors account for 75% of the risk of developing multiple sclerosis (MS). Numerous infections have been suspected as environmental disease triggers, but none of them has consistently been incriminated, and it is unclear how so many different infections may play a role. We show that a microbial peptide, common to several major classes of bacteria, can induce MS-like disease in humanized mice by crossreacting with a T cell receptor (TCR) that also recognizes a peptide from myelin basic protein, a candidate MS autoantigen. Structural analysis demonstrates this crossreactivity is due to structural mimicry of a binding hotspot shared by self and microbial antigens, rather than to degenerate TCR recognition. Biophysical studies reveal that the autoreactive TCR binding affinity is markedly lower for the microbial (mimicry) peptide than for the autoantigenic peptide. Thus, these data suggest a possible explanation for the difficulty in incriminating individual infections in the development of MS.

T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides., Harkiolaki M, Holmes SL, Svendsen P, Gregersen JW, Jensen LT, McMahon R, Friese MA, van Boxel G, Etzensperger R, Tzartos JS, Kranc K, Sainsbury S, Harlos K, Mellins ED, Palace J, Esiri MM, van der Merwe PA, Jones EY, Fugger L, Immunity. 2009 Mar 20;30(3):348-57. PMID:19303388

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

2wbj is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Harkiolaki M, Holmes SL, Svendsen P, Gregersen JW, Jensen LT, McMahon R, Friese MA, van Boxel G, Etzensperger R, Tzartos JS, Kranc K, Sainsbury S, Harlos K, Mellins ED, Palace J, Esiri MM, van der Merwe PA, Jones EY, Fugger L. T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides. Immunity. 2009 Mar 20;30(3):348-57. PMID:19303388 doi:10.1016/j.immuni.2009.01.009

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools