2wtd

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2wtd, resolution 2.75Å ()
Ligands: , ,
Activity: Non-specific serine/threonine protein kinase, with EC number 2.7.11.1
Related: 2cn8, 2w0j, 2w7x, 2wtc, 1gxc, 2cn5, 2wti, 2wtj
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml


Contents

CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR

Publication Abstract from PubMed

5-(Hetero)aryl-3-(4-carboxamidophenyl)-2-aminopyridine inhibitors of CHK2 were identified from high throughput screening of a kinase-focussed compound library. Rapid exploration of the hits through straightforward chemistry established structure-activity relationships and a proposed ATP-competitive binding mode which was verified by X-ray crystallography of several analogues bound to CHK2. Variation of the 5-(hetero)aryl substituent identified bicyclic dioxolane and dioxane groups which improved the affinity and the selectivity of the compounds for CHK2 versus CHK1. The 3-(4-carboxamidophenyl) substituent could be successfully replaced by acyclic omega-aminoalkylamides, which made additional polar interactions within the binding site and led to more potent inhibitors of CHK2. Compounds from this series showed activity in cell-based mechanistic assays for inhibition of CHK2.

Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2., Hilton S, Naud S, Caldwell JJ, Boxall K, Burns S, Anderson VE, Antoni L, Allen CE, Pearl LH, Oliver AW, Wynne Aherne G, Garrett MD, Collins I, Bioorg Med Chem. 2010 Jan 15;18(2):707-18. Epub 2009 Dec 6. PMID:20022510

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

2wtd is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Hilton S, Naud S, Caldwell JJ, Boxall K, Burns S, Anderson VE, Antoni L, Allen CE, Pearl LH, Oliver AW, Wynne Aherne G, Garrett MD, Collins I. Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2. Bioorg Med Chem. 2010 Jan 15;18(2):707-18. Epub 2009 Dec 6. PMID:20022510 doi:10.1016/j.bmc.2009.11.058

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