2z1z

From Proteopedia

Crystal structure of LL-Diaminopimelate Aminotransferase from Arabidopsis thaliana complexed with L-malate ion

Structural highlights

2z1z is a 2 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.4Å
Ligands:	MLT, PLP
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DAPAT_ARATH Required for lysine biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli. Not active with meso-diaminopimelate, lysine or ornithine as substrates.^[1] ^[2]

Evolutionary Conservation

Checkto colour the structure by Evolutionary Conservation, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Hudson AO, Singh BK, Leustek T, Gilvarg C. An LL-diaminopimelate aminotransferase defines a novel variant of the lysine biosynthesis pathway in plants. Plant Physiol. 2006 Jan;140(1):292-301. Epub 2005 Dec 16. PMID:16361515 doi:http://dx.doi.org/pp.105.072629
↑ Watanabe N, James MN. Structural insights for the substrate recognition mechanism of LL-diaminopimelate aminotransferase. Biochim Biophys Acta. 2011 Nov;1814(11):1528-33. doi:, 10.1016/j.bbapap.2011.03.008. Epub 2011 Mar 22. PMID:21435399 doi:http://dx.doi.org/10.1016/j.bbapap.2011.03.008

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 References

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PDB ID 2z1z

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2z1z

From Proteopedia

Crystal structure of LL-Diaminopimelate Aminotransferase from Arabidopsis thaliana complexed with L-malate ion

Structural highlights

Function

Evolutionary Conservation

References

Contents

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