3a8q
From Proteopedia
Low-resolution crystal structure of the Tiam2 PHCCEx domain
Structural highlights
FunctionTIAM2_MOUSE Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates specifically RAC1, but not CDC42 and RHOA. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane.[1] [2] [3] [4] [5] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. References
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Categories: Large Structures | Mus musculus | Hakoshima T | Higuchi Y | Itoh N | Kaibuchi K | Kitano K | Mori T | Terawaki S | Watanabe T | Zhai Y
