3ckv

From Proteopedia

Crystal Structure of a Mycobacterial Protein

Structural highlights

3ckv is a 1 chain structure with sequence from Mycobacterium avium subsp. paratuberculosis K-10. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2Å
Ligands:	GOL, SO4, UDP
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GPGS_MYCPA Involved in the biosynthesis of methylglucose lipopolysaccharides (MGLPs). Catalyzes the condensation of UDP-glucose and 3-phospho-glycerate (3-PGA) to yield glucosyl-3-phosphoglycerate (GPG). Although UDP-glucose is the natural donor sugar, GpgS can also use UDP-GalNAc, UDPGlcNAc, UDP-alpha-L-arabinose, UDP-Gal, UDP-Glc, UDP-alpha-Dglucuronic acid, and UDP-alpha-D-xylose as donor substrates.^[1]

Evolutionary Conservation

Checkto colour the structure by Evolutionary Conservation, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Fulton Z, McAlister A, Wilce MC, Brammananth R, Zaker-Tabrizi L, Perugini MA, Bottomley SP, Coppel RL, Crellin PK, Rossjohn J, Beddoe T. Crystal structure of a UDP-glucose-specific glycosyltransferase from a Mycobacterium species. J Biol Chem. 2008 Oct 10;283(41):27881-90. Epub 2008 Jul 30. PMID:18667419 doi:10.1074/jbc.M801853200

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 References

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PDB ID 3ckv

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Categories: Large Structures | Mycobacterium avium subsp. paratuberculosis K-10 | Marland Z | Rossjohn J

3ckv

From Proteopedia

Crystal Structure of a Mycobacterial Protein

Structural highlights

Function

Evolutionary Conservation

References

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