3dfz

Structural highlights

Function

SIRC_PRIMG Catalyzes the dehydrogenation of precorrin-2 to form sirohydrochlorin which is used as a precursor in both siroheme biosynthesis and in the anaerobic branch of adenosylcobalamin biosynthesis. It is unable to oxidize precorrin-3.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Raux E, Leech HK, Beck R, Schubert HL, Santander PJ, Roessner CA, Scott AI, Martens JH, Jahn D, Thermes C, Rambach A, Warren MJ. Identification and functional analysis of enzymes required for precorrin-2 dehydrogenation and metal ion insertion in the biosynthesis of sirohaem and cobalamin in Bacillus megaterium. Biochem J. 2003 Mar 1;370(Pt 2):505-16. PMID:12408752 doi:http://dx.doi.org/10.1042/BJ20021443
2. ↑ Schubert HL, Rose RS, Leech HK, Brindley AA, Hill CP, Rigby SE, Warren MJ. Structure and function of SirC from Bacillus megaterium: a metal-binding precorrin-2 dehydrogenase. Biochem J. 2008 Oct 15;415(2):257-63. PMID:18588505 doi:10.1042/BJ20080785