Structural highlights
Function
DNRF_STREF Involved in the biosynthesis of the anthracyclines carminomycin, rhodomycin and daunorubicin (daunomycin) which are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. Catalyzes the incorporation of a hydroxyl group at position C-11 of aklavinone, resulting in epsilon-rhodomycinone. It cannot accept substrates glycosylated at position C-7 and is specific for the C-9R configuration of anthracyclines. It can use both NAD or NADP but it is slowly inactivated in the presence of NADH.[1] [2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Niemi J, Wang Y, Airas K, Ylihonko K, Hakala J, Mäntsälä P. Characterization of aklavinone-11-hydroxylase from Streptomyces purpurascens. Biochim Biophys Acta. 1999 Feb 10;1430(1):57-64. PMID:10082933 doi:10.1016/s0167-4838(98)00265-9
- ↑ Lindqvist Y, Koskiniemi H, Jansson A, Sandalova T, Schnell R, Liu Z, Mantsala P, Niemi J, Schneider G. Structural basis for substrate recognition and specificity in aklavinone-11-hydroxylase from rhodomycin biosynthesis. J Mol Biol. 2009 Nov 6;393(4):966-77. Epub 2009 Sep 8. PMID:19744497 doi:10.1016/j.jmb.2009.09.003
