3kam

From Proteopedia

Hen Egg White Lysozyme Derivatized with rhenium(I) diaquatricarbonyl cation

Structural highlights

3kam is a 1 chain structure with sequence from Gallus gallus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.59Å
Ligands:	, , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LYSC_CHICK Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The reaction of Re(CO)(3)(H(2)O)(3)(+) with hen egg lysozyme in aqueous solution results in a single covalent adduct; single crystal X-ray diffraction shows that the rhenium tricarbonyl cation binds to His15 in two significantly populated rotamer conformations.

Specific derivatization of lysozyme in aqueous solution with Re(CO)3(H2O)3(+).,Binkley SL, Ziegler CJ, Herrick RS, Rowlett RS Chem Commun (Camb). 2010 Feb 28;46(8):1203-5. Epub 2010 Jan 9. PMID:20449250^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Maehashi K, Matano M, Irisawa T, Uchino M, Kashiwagi Y, Watanabe T. Molecular characterization of goose- and chicken-type lysozymes in emu (Dromaius novaehollandiae): evidence for extremely low lysozyme levels in emu egg white. Gene. 2012 Jan 15;492(1):244-9. doi: 10.1016/j.gene.2011.10.021. Epub 2011 Oct, 25. PMID:22044478 doi:10.1016/j.gene.2011.10.021
↑ Binkley SL, Ziegler CJ, Herrick RS, Rowlett RS. Specific derivatization of lysozyme in aqueous solution with Re(CO)3(H2O)3(+). Chem Commun (Camb). 2010 Feb 28;46(8):1203-5. Epub 2010 Jan 9. PMID:20449250 doi:10.1039/b923688k