3lkk

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Crystal structure of the isopentenyl phosphate kinase substrate complex

Structural highlights

3lkk is a 2 chain structure with sequence from Thermoplasma acidophilum DSM 1728. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.001Å
Ligands:ATP, IP8
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

IPK_THEAC Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. Has lower activity with isopentenyl thiolophosphate (ISP). Has low activity with dimethylallyl phosphate (DMAP), 1-butyl phosphate (BP) and 3-buten-1-yl phosphate (BEP). Has no significant activity with geranyl phosphate (in vitro).[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Chen M, Poulter CD. Characterization of thermophilic archaeal isopentenyl phosphate kinases. Biochemistry. 2010 Jan 12;49(1):207-17. PMID:19928876 doi:10.1021/bi9017957

Contents


PDB ID 3lkk

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OCA

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