Structural highlights
Function
NCAP_RVFV Encapsidates the genomic RNA, protecting it from nucleases (Probable) (PubMed:20547879). Displays high affinity for single-stranded nucleic acid (PubMed:23129612). The encapsidated genomic RNA is termed the nucleocapsid (NC) or ribonucleoprotein (PubMed:20547879). The ribonucleoprotein has a non-helical structure (PubMed:20547879). Serves as template for viral transcription and replication (By similarity). After replication, the nucleocapsid is recruited to the host Golgi apparatus by glycoprotein Gn for packaging into virus particles (By similarity).[UniProtKB:P21700][1] [2] [3]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Raymond DD, Piper ME, Gerrard SR, Smith JL. Structure of the Rift Valley fever virus nucleocapsid protein reveals another architecture for RNA encapsidation. Proc Natl Acad Sci U S A. 2010 Jun 14. PMID:20547879
- ↑ Raymond DD, Piper ME, Gerrard SR, Skiniotis G, Smith JL. Phleboviruses encapsidate their genomes by sequestering RNA bases. Proc Natl Acad Sci U S A. 2012 Nov 5. PMID:23129612 doi:10.1073/pnas.1213553109
- ↑ Hayashi M, Schultz EP, Lanchy JM, Lodmell JS. Time-Resolved Analysis of N-RNA Interactions during RVFV Infection Shows Qualitative and Quantitative Shifts in RNA Encapsidation and Packaging. Viruses. 2021 Dec 2;13(12). pii: v13122417. doi: 10.3390/v13122417. PMID:34960686 doi:http://dx.doi.org/10.3390/v13122417
