3n71

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Crystal structure of cardiac specific histone methyltransferase SmyD1

Structural highlights

3n71 is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Ligands:GOL, MES, SFG, ZN
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SMYD1_MOUSE Methylates histone H3 at 'Lys-4' (H3K4me). Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis.[1] [2]

See Also

References

  1. ↑ Gottlieb PD, Pierce SA, Sims RJ, Yamagishi H, Weihe EK, Harriss JV, Maika SD, Kuziel WA, King HL, Olson EN, Nakagawa O, Srivastava D. Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis. Nat Genet. 2002 May;31(1):25-32. Epub 2002 Apr 1. PMID:11923873 doi:http://dx.doi.org/10.1038/ng866
  2. ↑ Sirinupong N, Brunzelle J, Ye J, Pirzada A, Nico L, Yang Z. Crystal structure of cardiac specific histone methyltransferase SmyD1 reveals unusual active site architecture. J Biol Chem. 2010 Oct 12. PMID:20943667 doi:10.1074/jbc.M110.168187

Contents


PDB ID 3n71

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OCA

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