3ov3

Structural highlights

Function

CURS1_CURLO Catalyzes the synthesis of curcumin by condensing feruloyl-CoA with a diketide-CoA in the curcuminoid biosynthesis.^{[1] [2]}

References

1. ↑ Katsuyama Y, Kita T, Funa N, Horinouchi S. Curcuminoid biosynthesis by two type III polyketide synthases in the herb Curcuma longa. J Biol Chem. 2009 Apr 24;284(17):11160-70. PMID:19258320 doi:10.1074/jbc.M900070200
2. ↑ Katsuyama Y, Miyazono K, Tanokura M, Ohnishi Y, Horinouchi S. Structural and biochemical elucidation of mechanism for decarboxylative condensation of beta-keto acid by curcumin synthase. J Biol Chem. 2011 Feb 25;286(8):6659-68. PMID:21148316 doi:10.1074/jbc.M110.196279