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3pmv

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3pmv, resolution 1.80Å ()
Ligands: , , ,
Gene: Gria2, Glur2 (Rattus norvegicus)
Related: 3o28, 3o29, 3o2a, 3o6g, 3o6h, 3o6i, 3pmw, 3pmx


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Contents

Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator

Publication Abstract from PubMed

Starting from compound 1, we utilized biostructural data to successfully evolve an existing series into a new chemotype with a promising overall profile, exemplified by 19.

Structure based evolution of a novel series of positive modulators of the AMPA receptor., Jamieson C, Maclean JK, Brown CI, Campbell RA, Gillen KJ, Gillespie J, Kazemier B, Kiczun M, Lamont Y, Lyons AJ, Moir EM, Morrow JA, Pantling J, Rankovic Z, Smith L, Bioorg Med Chem Lett. 2011 Jan 15;21(2):805-11. Epub 2010 Nov 25. PMID:21190850

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

3pmv is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

See Also

Reference

  • Jamieson C, Maclean JK, Brown CI, Campbell RA, Gillen KJ, Gillespie J, Kazemier B, Kiczun M, Lamont Y, Lyons AJ, Moir EM, Morrow JA, Pantling J, Rankovic Z, Smith L. Structure based evolution of a novel series of positive modulators of the AMPA receptor. Bioorg Med Chem Lett. 2011 Jan 15;21(2):805-11. Epub 2010 Nov 25. PMID:21190850 doi:10.1016/j.bmcl.2010.11.098
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