3qkw

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Structure of Streptococcus parasangunini Gtf3 glycosyltransferase

Structural highlights

3qkw is a 4 chain structure with sequence from Streptococcus parasanguinis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.287Å
Ligands:UDP
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GTF3_STRPA Required for polymorphic O-glycosylation of the serine-rich repeat protein Fap1. Catalyzes the second step in glycosylation of the serine-rich repeat protein in this bacteria. Transfers glucose from UDP-glucose to the terminal GlcNAc moiety of 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-seryl-[protein] which results from the first glycosylation step of Fap1; does not use other sugar nucleotides as substrates.[1] [2] [3]

References

  1. ↑ Zhou M, Zhu F, Dong S, Pritchard DG, Wu H. A novel glucosyltransferase is required for glycosylation of a serine-rich adhesin and biofilm formation by Streptococcus parasanguinis. J Biol Chem. 2010 Apr 16;285(16):12140-8. PMID:20164186 doi:10.1074/jbc.M109.066928
  2. ↑ Zhu F, Erlandsen H, Ding L, Li J, Huang Y, Zhou M, Liang X, Ma J, Wu H. Structural and functional analysis of a new subfamily of glycosyltransferases required for glycosylation of serine-rich streptococcal adhesins. J Biol Chem. 2011 Jun 7. PMID:21653318 doi:10.1074/jbc.M110.208629
  3. ↑ Zhu F, Zhang H, Wu H. A conserved domain is crucial for acceptor substrate binding in a family of glucosyltransferases. J Bacteriol. 2015 Feb;197(3):510-7. doi: 10.1128/JB.02267-14. Epub 2014 Nov 17. PMID:25404702 doi:http://dx.doi.org/10.1128/JB.02267-14

Contents


PDB ID 3qkw

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