3rc9

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Crystal Structure of the K102A mutant of KijD10, a 3-ketoreductase from Actinomadura kijaniata in complex with TDP-benzene and NADP

Structural highlights

3rc9 is a 1 chain structure with sequence from Actinomadura kijaniata. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.91Å
Ligands:CL, NA, NAP, PO4, TLO
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KIJDR_ACTKI Involved in the biosynthesis of L-digitoxose, an unusual dideoxysugar attached to various pharmacologically active natural products, including the antitumor antibiotic tetrocarcin A, and the antibiotics kijanimicin and jadomycin B. Catalyzes the reduction of the C-3 keto moiety of dTDP-3,4-diketo-2,6-dideoxy-alpha-D-glucose to yield dTDP-4-keto-2,6-dideoxy-alpha-D-glucose. Also able to reduce dTDP-3-keto-6-deoxy-D-galactose and dTDP-3-keto-6-deoxy-D-glucose to yield dTDP-fucose and dTDP-quinovose, respectively.[1]

References

  1. ↑ Kubiak RL, Holden HM. A Combined Structural and Functional Investigation of a C-3-Ketoreductase Involved in the Biosynthesis of dTDP-L-Digitoxose. Biochemistry. 2011 May 20. PMID:21598943 doi:10.1021/bi200514b

Contents


PDB ID 3rc9

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